Skip to main content

3-Quinuclidinol

ADVERTISEMENT
Identification
Molecular formula
C7H13NO
CAS number
1619-34-7
IUPAC name
quinuclidin-3-ol
State
State

At room temperature, 3-Quinuclidinol is in solid state. It is stable under normal conditions and should be stored properly to maintain its crystalline integrity.

Melting point (Celsius)
227.00
Melting point (Kelvin)
500.15
Boiling point (Celsius)
256.00
Boiling point (Kelvin)
529.15
General information
Molecular weight
129.20g/mol
Molar mass
129.1970g/mol
Density
1.0370g/cm3
Appearence

3-Quinuclidinol typically appears as a white crystalline solid. It is commonly encountered in its pure form as a fine powder but can also be found in crystalline form depending on its processing and storage conditions.

Comment on solubility

Solubility of Quinuclidin-3-ol

Quinuclidin-3-ol, a bicyclic amine, exhibits distinct solubility characteristics that are essential for its applications. Here are some noteworthy points regarding its solubility:

  • Polarity: The presence of a hydroxyl (-OH) group in quinuclidin-3-ol makes it a polar compound, contributing to its solubility in polar solvents.
  • Solvent Compatibility: Quinuclidin-3-ol is soluble in water, due to hydrogen bonding involving the hydroxyl group, and can also dissolve in various organic solvents like alcohols and ethers.
  • Limitations: Its solubility in non-polar solvents is limited, which can restrict its use in certain chemical processes where non-polar solvents are preferred.

As a general observation, the solubility of quinuclidin-3-ol demonstrates how functional groups in a compound influence its interaction with different solvents. In practical terms, this makes it a suitable candidate in formulations where a balance between polar and non-polar properties is desired.

In summary, understanding the solubility of quinuclidin-3-ol helps scientists and researchers optimize its utility in various chemical applications. As the saying goes, “like dissolves like,” emphasizing the importance of polarity in solubility.

Interesting facts

Quinuclidin-3-ol: An Overview

Quinuclidin-3-ol, a bicyclic compound, has garnered interest within the realms of medicinal chemistry and pharmacology. This intriguing compound is known for its role as a versatile intermediate in the synthesis of various pharmaceuticals. Researchers are captivated by its potential, as the structural framework of quinuclidin-3-ol provides a foundation for the development of drug candidates with improved efficacy and safety profiles.

Key Characteristics and Applications

Some notable aspects of quinuclidin-3-ol include:

  • Neuropharmacological Activity: Due to its structural similarity to other biologically active compounds, quinuclidin-3-ol has shown potential for modulating neurotransmitter receptors, particularly in the central nervous system.
  • Synthesis of Derivatives: Its functionality makes it a valuable building block in the synthesis of various quinuclidine derivatives, which may possess improved pharmacological properties.
  • Research Relevance: Scientists are actively exploring its applications in fields such as drug design, where its unique properties can lead to novel therapeutic agents.

In the Laboratory

The laboratory synthesis of quinuclidin-3-ol involves applying established methodologies in organic chemistry. This compound serves as a significant point of reference in reaction pathways due to its utility in preparing other important compounds. As one chemist noted, "Quinuclidin-3-ol is more than just a molecule; it's a gateway to understanding complex biological synergies."

In summary, quinuclidin-3-ol stands out not only for its intriguing structure but also for its wide-ranging implications in medicine and chemistry. Its continued study offers promising avenues for innovations in drug development and biological understanding.

Synonyms
3-QUINUCLIDINOL
1619-34-7
Quinuclidin-3-ol
1-Azabicyclo[2.2.2]octan-3-ol
3-Hydroxyquinuclidine
Quinuclidinol
3-Quinuclidinol dl-form
(+-)-3-quinuclidinol
1-Aza-bicyclo[2.2.2]octan-3-ol
3-Hydroxy-1-azabicyclo[2.2.2]octane
1-Azabicyclo(2.2.2)octan-3-ol
NSC 93905
EINECS 216-578-4
974MVZ0WOK
BRN 0104327
HSDB 7710
CHEBI:115239
NSC-93905
3-QUINUCLIDINOL, DL-
DTXSID50862716
3-QUINUCLIDINOL DL-FORM [MI]
1-Aza-bicyclo(2.2.2)octan-3-ol
1-Azabicyclo[2.2.2.]octan-3-ol
3-hydroxy-1-azabicyclo(2.2.2)octane
1-AZABICYCLO(2.2.2.)OCTAN-3-OL
DTXCID60218745
3-QUINUCLIDINOL, (+-)-
3-HYDROXYQUINUCLIDINE, (+-)-
216-578-4
Quinuclidine-3-ol
CHEMBL276310
3-hydroxy quinuclidine
UNII-974MVZ0WOK
quinuclidone-3
3-quinuclidol
Quinuclidinol-3
3-oxyquinuclidine
3-hydroxychinuclidin
(RS) 3-quinuclidinol
(RS)-3-Quinuclidinol
(+/-)3-Quinuclidinol
(rac.)-3-quinuclidinol
3-Quinuclidinol, 99%
racemic quinuclidin-3-ol
(+/-)-3-Quinuclidinol
SCHEMBL66150
CS-B0695
NSC93905
BDBM50047005
MFCD00151326
3-QUINUCLIDINOL, (+/-)-
AKOS009158263
aza-bicyclo[2.2.2]oct-3-yl alcohol
AB87536
FQ03755
PS-5754
SB13175
SDCCGMLS-0065888.P001
3-HYDROXYQUINUCLIDINE, (+/-)-
3-hydroxy-1-azoniabicyclo[2.2.2]octane
3684-26-2
PD060385
DB-043508
DB-082764
NS00006113
Q0024
1-azabicyclo[2.2.2]octan-3-ol,hydrochloride
F11430
A810307
1-Aza-bicyclo[2.2.2]octan-3-ol (3-quinuclidinol)
1-Azabicyclo[2.2.2]octan-3-ol;3-Hydroxyquinuclidine
Q27197086
InChI=1/C7H13NO/c9-7-5-8-3-1-6(7)2-4-8/h6-7,9H,1-5H