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3-Quinuclidinone

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Identification
Molecular formula
C7H11NO
CAS number
3731-38-2
IUPAC name
quinuclidin-3-one
State
State

3-Quinuclidinone is typically found as a solid at room temperature.

Melting point (Celsius)
156.00
Melting point (Kelvin)
429.15
Boiling point (Celsius)
248.00
Boiling point (Kelvin)
521.15
General information
Molecular weight
111.16g/mol
Molar mass
111.1580g/mol
Density
1.0430g/cm3
Appearence

3-Quinuclidinone is a crystalline solid. Its appearance can range from white to off-white powder depending on purity and particle size.

Comment on solubility

Solubility of Quinuclidin-3-one

Quinuclidin-3-one, with the chemical formula C7H11NO, exhibits intriguing solubility characteristics that are essential for various applications in organic synthesis and pharmaceuticals. Here are some key points regarding its solubility:

  • Polar and Non-Polar Solvents: Quinuclidin-3-one is generally soluble in polar solvents, such as water and alcohols, due to its polar amine and carbonyl functional groups. This solubility in polar media makes it suitable for reactions and formulations that require a liquid phase.
  • Limited Solubility in Non-Polar Solvents: Conversely, this compound exhibits limited solubility in non-polar solvents, which can hinder its use in certain organic reactions where a non-polar medium is favored.
  • Temperature Dependence: The solubility may vary significantly with temperature. As is common with many organic compounds, increasing the temperature can enhance solubility, promoting more favorable interactions with the solvent.
  • pH Sensitivity: The solubility of quinuclidin-3-one may also be influenced by the pH of the solution, as the ionization of functional groups can lead to changes in solubility behavior.

In summary, the solubility of quinuclidin-3-one highlights its versatility and the importance of solvent choice in applications. As it is soluble in polar solvents and exhibits limited solubility in non-polar environments, understanding these solubility properties is key for effective use in various chemical contexts.

Interesting facts

Interesting Facts about Quinuclidin-3-one

Quinuclidin-3-one is an intriguing compound that falls within the category of bicyclic organic compounds. Known for its unique structure, it has garnered attention in various fields of research. Here are some compelling aspects of this versatile compound:

  • Structural Features: Quinuclidin-3-one boasts a bicyclic structure, which provides a platform for various chemical reactions and interactions, making it valuable in synthetic organic chemistry.
  • Importance in Pharmacology: This compound is of particular interest in medicinal chemistry. Its derivatives have been studied for their potential as anticholinergic agents and their use in treating conditions like asthma and chronic obstructive pulmonary disease (COPD).
  • Role in Neuroscience: Quinuclidin-3-one is also noted for its influence on neurological research. It serves as a precursor for the synthesis of various neurotransmitter modulators, aiding in studies related to cognitive functions.
  • Chemical Reactivity: The presence of a carbonyl group in quinuclidin-3-one makes it a reactive participant in various chemical processes, such as Michael additions and condensation reactions, which are essential in synthetic pathways.
  • Research Applications: Researchers are continuously exploring the compound for its potential use in creating innovative pharmaceuticals. For instance, chemists have been interested in developing quinuclidine-based ligands that can bind to specific receptors in the body.

In summary, quinuclidin-3-one is a fascinating compound that not only exhibits interesting structural characteristics but also holds promise in various scientific applications, particularly in the fields of pharmacology and neuroscience. As research progresses, the potential uses and functionalities of quinuclidin-3-one may continue to expand, leading to groundbreaking discoveries.

Synonyms
Quinuclidin-3-one
3-Quinuclidinone
1-Azabicyclo[2.2.2]octan-3-one
Quinuclidone
Quinuclidone 3
1-AZABICYCLO(2.2.2)OCTAN-3-ONE
EINECS 223-087-9
DTXSID0063151
EC 223-087-9
DTXCID9039313
223-087-9
inchi=1/c7h11no/c9-7-5-8-3-1-6(7)2-4-8/h6h,1-5h
zkmzpxwmmsblno-uhfffaoysa-n
3731-38-2
3-Quinuclidone
3-Oxoquinuclidine
MKC-2
P4VF4G5PTA
NSC 168448
1-aza-bicyclo[2.2.2]octan-3-one
NSC-168448
quinuclidine-3-one
MFCD06801385
UNII-P4VF4G5PTA
SCHEMBL161762
CHEMBL377716
1-azabicyclo[2.2.2]octan-8-one
CS-B0309
AC-713
NSC168448
STL069553
AKOS000119728
AKOS015949293
IQ31367
SB36886
s12072
NS00001279
Solifenacin related compound 22;Quinuclidin-3-one