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Tropisetron

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Identification
Molecular formula
C17H20N2O2
CAS number
89565-68-4
IUPAC name
quinuclidin-3-yl 2-hydroxytricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxylate
State
State

Solid: At room temperature, tropisetron is in a solid-state as a crystalline powder. It maintains its solid state and does not melt until reaching its melting point of 158 °C.

Melting point (Celsius)
158.00
Melting point (Kelvin)
431.15
Boiling point (Celsius)
368.15
Boiling point (Kelvin)
641.15
General information
Molecular weight
285.37g/mol
Molar mass
285.3660g/mol
Density
1.3273g/cm3
Appearence

Tropisetron appears as a white to off-white powder. It is crystalline in nature, allowing it to be characterized by its specific structure and particle size, typical for pharmaceutical-grade powders.

Comment on solubility

Solubility of Quinuclidin-3-yl 2-Hydroxytricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxylate

The solubility of quinuclidin-3-yl 2-hydroxytricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxylate can be quite complex due to its unique structural characteristics. Here are some key points regarding its solubility:

  • Polarity Impact: The presence of polar functional groups, such as the -OH and -COO groups, generally enhances solubility in polar solvents like water.
  • Steric Hindrance: The tricyclic structure may introduce steric hindrance, which can limit the compound's interaction with solvent molecules.
  • Solvent Versatility: This compound may exhibit differential solubility in various solvents, being more soluble in organic solvents like ethanol or DMSO compared to water.
  • Temperature Dependence: Solubility may increase with temperature, a common trait among many organic compounds, but specific data would be required for accurate quantification.

In conclusion, the solubility behavior of quinuclidin-3-yl 2-hydroxytricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxylate ultimately hinges on its structural properties and the nature of the solvent used. Further empirical studies would provide clarity regarding its solubility profile in different environments.

Interesting facts

Interesting Facts about Quinuclidin-3-yl 2-hydroxytricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxylate

Quinuclidin-3-yl 2-hydroxytricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxylate is a fascinating compound that lies at the intersection of organic chemistry and medicinal applications. Here are some noteworthy aspects:

  • **Structural Complexity**: The compound features a unique tricyclic structure which often leads to diverse chemical behavior. Its intricate framework can influence its biological activity significantly.
  • **Potential Pharmacological Applications**: Compounds with quinuclidine moieties are known for their potential as therapeutic agents. They have been studied for use as anticholinergic drugs and may contribute to the development of treatments for neurological disorders.
  • **Stereochemistry**: The spatial arrangement of atoms in this compound is crucial. Stereochemistry can affect how the compound interacts with biological targets, showcasing the importance of chirality in drug design.
  • **Natural Inspirations**: The cyclohexene and quinuclidine frameworks are inspired by natural alkaloids, often providing insights into the design of new compounds modeled after biologically active molecules.
  • **Research Significance**: Ongoing studies aim to investigate the reactivity and stability of this compound, which could lead to advancements in synthetic methodologies and applications in fine chemical production.

In summary, the unique structural elements and potential applications of quinuclidin-3-yl 2-hydroxytricyclo[9.4.0.03,8]pentadeca-1(15),3,5,7,11,13-hexaene-2-carboxylate make it a noteworthy subject of research. As scientists continue to explore its properties, we can expect to uncover new avenues for therapeutic discovery and innovation.

Synonyms
BRN 1510210
3-Quinuclidyl 5-hydroxy-10,11-dihydro-(5H)-dibenzo(a,d)cycloheptene-5-carboxylate
10541-19-2
5H-Dibenzo(a,d)cycloheptene-5-carboxylic acid, 10,11-dihydro-5-hydroxy-, 3-quinuclidinyl ester
DTXSID00909524
AM-814/41093242
1-azabicyclo[2.2.2]oct-3-yl 5-hydroxy-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-carboxylate
1-Azabicyclo[2.2.2]octan-3-yl 5-hydroxy-10,11-dihydro-5H-dibenzo[a,d][7]annulene-5-carboxylate