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Quinuclidin-3-yl acetate

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Identification
Molecular formula
C9H17NO2
CAS number
18454-84-9
IUPAC name
quinuclidin-3-yl acetate
State
State

At room temperature, quinuclidin-3-yl acetate is a solid. It is typically managed in its solid form for chemical reactions and storage.

Melting point (Celsius)
96.00
Melting point (Kelvin)
369.15
Boiling point (Celsius)
233.00
Boiling point (Kelvin)
506.15
General information
Molecular weight
171.24g/mol
Molar mass
197.2730g/mol
Density
1.0926g/cm3
Appearence

Quinuclidin-3-yl acetate is a crystalline solid that can appear as white powder. The compound is known for its characteristic odor and is often utilized in chemical synthesis.

Comment on solubility

Solubility of Quinuclidin-3-yl Acetate

Quinuclidin-3-yl acetate (C9H17NO2) exhibits intriguing solubility characteristics that can significantly influence its application in various fields, especially in pharmaceuticals.

  • Solubility in Water: Quinuclidin-3-yl acetate is generally considered to have low water solubility. This can be attributed to its hydrophobic quinuclidine ring structure, leading to limited interactions with water molecules.
  • Solubility in Organic Solvents: The compound shows better solubility in organic solvents such as ethanol and chloroform, making it suitable for formulations that require non-aqueous environments.
  • Temperature Dependence: As with many organic compounds, solubility may increase with temperature. This implies that a slight increase in temperature can enhance its solubility in organic solvents.

While working with Quinuclidin-3-yl acetate, it is essential to consider the following points:

  • The choice of solvent can greatly influence the compound's availability and effectiveness in reactions.
  • Low solubility in water necessitates special considerations when formulating aqueous solutions for biological studies or pharmaceutical applications.

Understanding the solubility profile of Quinuclidin-3-yl acetate is crucial for optimizing its use in laboratory settings and industrial applications. As the saying goes, “solubility is the key to utility” in chemical processes!

Interesting facts

Interesting Facts about Quinuclidin-3-yl Acetate

Quinuclidin-3-yl acetate is a fascinating compound primarily studied for its relevance in the field of medicinal chemistry. Here are some key points that make this compound particularly interesting:

  • Pharmacological Potential: Quinuclidin-3-yl acetate is a derivative of quinuclidine, a bicyclic compound known for its biological activity. Its structure allows it to interact with various neurotransmitter receptors, making it a candidate for research in neurology and psychiatry.
  • Anticholinergic Activity: This compound exhibits anticholinergic properties, which means it can inhibit the action of acetylcholine, a crucial neurotransmitter. This activity has implications in treating conditions such as Parkinson's disease and certain gastrointestinal disorders.
  • Synthesis and Reactions: The synthesis of quinuclidin-3-yl acetate involves the acetylation of quinuclidine. This reaction showcases the versatility of organic reactions and highlights the importance of functional group manipulation in drug design.
  • Research Applications: Quinuclidin-3-yl acetate is employed in various research studies to explore its effects on the central nervous system. This compound is valuable for understanding synaptic transmission and for the development of novel therapeutic agents.
  • Chemical Derivatives: The study of quinuclidin-3-yl acetate has led to the development of numerous derivatives, each with distinct biological activities, thus broadening the scope of pharmacological research in treating a variety of ailments.

In conclusion, quinuclidin-3-yl acetate embodies the intersection of organic chemistry and pharmacology, offering insights into the development of new therapeutic agents. The ongoing research surrounding this compound exemplifies the dynamic nature of chemical science and its potential to contribute to medical advancements.

Synonyms
aceclidine
827-61-2
Quinuclidin-3-yl acetate
3-Acetoxyquinuclidine
1-azabicyclo[2.2.2]octan-3-yl acetate
3-Quinuclidinol acetate (ester)
Glaucostat
Aceclidinum
Aceclidina
1-Azabicyclo(2.2.2)octan-3-ol, acetate (ester)
3-Quinuclidinol, acetate (ester)
MFCD00468105
NSC-657843
NSC-758239
CHEMBL20835
1-Azabicyclo(2.2.2)octan-3-ol, acetate
0578K3ELIO
DTXSID2045658
1-Azabicyclo[2.2.2]octan-3-ol, acetate (ester)
NSC657843
NCGC00024733-02
3-Quinuclidinol acetate
Aceclidine [USAN:INN]
Aceclidinum [INN-Latin]
Aceclidina [INN-Spanish]
1-Azabicyclo[2.2.2]octan-3-ol, acetate
3-quinuclidinyl acetate
Quinuclidin-3-ylacetate
EINECS 212-574-1
AL 304
UNII-0578K3ELIO
Glaucostat (TN)
aceclidine,R(-)
aceclidine,S(+)
NSC 657843
Spectrum_001338
ACECLIDINE [INN]
3-Quinuclidinol, acetate
Aceclidine (USAN/INN)
Spectrum2_001235
Spectrum3_001446
Spectrum4_000421
Spectrum5_001301
ACECLIDINE [USAN]
ACECLIDINE [MART.]
(RS)-3-acetoxyquinuclidine
ACECLIDINE [WHO-DD]
(+) 3-acetoxy quinuclidine
BSPBio_002911
KBioGR_000742
KBioSS_001818
(RS) 3-acetoxy quinuclidine
DivK1c_000180
SCHEMBL121393
SPBio_001110
DTXCID0025658
CHEBI:93847
KBio1_000180
KBio2_001818
KBio2_004386
KBio2_006954
KBio3_002411
NINDS_000180
HMS3264B20
Pharmakon1600-01501124
acetic acid quinuclidin-3-yl ester
CS-B0278
Tox21_110921
BDBM50034625
NSC758239
STL430459
AKOS006281409
CCG-212926
DB13262
DS-5025
1-Azabicyclo[2.2.2]oct-3-yl acetate
IDI1_000180
3-quinuclidinol dl-form acetate (ester)
NCGC00024733-03
NCGC00024733-04
CAS-827-61-2
DA-50124
HY-32067
NCI60_020173
NCI60_020184
SY111901
1-Azabicyclo[2.2.2]oct-3-yl acetate #
NS00006968
D02750
AB00053601_02
AB00053601_03
EN300-3463436
Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester
acetic acid 1-azabicyclo[2.2.2]octan-3-yl ester
L023942
Q2362603
3-QUINUCLIDINOL DL-FORM ACETATE (ESTER) [MI]
BRD-A32673558-001-01-7
BRD-A32673558-001-02-5
BRD-A32673558-003-02-1
BRD-A32673558-003-03-9
BRD-A80567352-003-01-6
BRD-A80567352-003-02-4
Acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester(aceclidine)