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Tolterodine

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Identification
Molecular formula
C22H31NO2
CAS number
124937-52-6
IUPAC name
quinuclidin-3-yl N-(o-tolyl)carbamate
State
State

At room temperature, tolterodine is a solid. It is usually handled in powder form and should be stored in a dry environment to prevent degradation. Tolterodine's chemical stability makes it suitable for long-term storage under controlled conditions.

Melting point (Celsius)
121.00
Melting point (Kelvin)
394.00
Boiling point (Celsius)
314.50
Boiling point (Kelvin)
587.70
General information
Molecular weight
307.50g/mol
Molar mass
307.4100g/mol
Density
1.1803g/cm3
Appearence

Tolterodine is a white, crystalline solid that is typically provided in the form of tartrate salt for pharmaceutical applications. It is practically insoluble in water, meaning it does not dissolve easily. The compound has a specific crystalline appearance under microscopic evaluation, usually in its pure form.

Comment on solubility

Solubility of Quinuclidin-3-yl N-(o-tolyl)carbamate

Quinuclidin-3-yl N-(o-tolyl)carbamate is an intriguing compound when it comes to its solubility characteristics. Solubility is determined by several factors, including molecular structure and the presence of functional groups. For this compound, consider the following aspects:

  • Polarity: The presence of a carbamate group typically increases the polarity of the molecule, which may enhance its solubility in polar solvents like water.
  • Non-polar characteristics: The o-tolyl group contributes a non-polar character, which can lead to better solubility in organic solvents such as ethanol or chloroform.
  • Hydrogen bonding: The possibility of hydrogen bonding with water molecules could further facilitate solubility in aqueous environments.
  • Temperature dependence: As with many compounds, solubility may vary with temperature; increased temperatures often lead to enhanced solubility.

To succinctly summarize:

  • Potentially soluble in polar solvents due to the carbamate group.
  • May demonstrate better solubility in organic solvents owing to its hydrophobic components.
  • Temperature fluctuations can affect overall solubility characteristics.

In conclusion, the solubility of quinuclidin-3-yl N-(o-tolyl)carbamate presents a complex balance between polar and non-polar interactions, demonstrating the fascinating interplay of its molecular structure. Understanding these factors can provide valuable insights into its practical applications and behavior in various environments.

Interesting facts

Interesting Facts about Quinuclidin-3-yl N-(o-tolyl)carbamate

Quinuclidin-3-yl N-(o-tolyl)carbamate is a fascinating compound with notable implications in pharmacology and medicinal chemistry. Here are some intriguing aspects of this compound:

  • Targeted Applications: This compound belongs to a class known for its activity as anticholinergics, which means it can affect the neurotransmitter acetylcholine in the central and peripheral nervous systems. This opens possibilities for therapeutic uses in managing various conditions, including motion sickness and muscle spasms.
  • Synthetic Versatility: The synthesis of this compound can serve as a valuable example of modern organic chemistry techniques, showcasing the ability to create complex structures with specific functional groups that can modulate biological activity.
  • Structure-Activity Relationship (SAR): Studying this compound can provide insights into the SAR, enabling scientists to understand how modifications to its structure can enhance or diminish its pharmacological properties.
  • Historical Context: Compounds in this category have historical significance in drug discovery, dating back decades when anticholinergic agents were first explored, paving the way for innovations in neurology and psychopharmacology.

In the words of a renowned chemist, “The beauty of organic compounds lies not just in their structure, but in their potential to change lives.” Quinuclidin-3-yl N-(o-tolyl)carbamate epitomizes this principle by bridging the gap between molecular design and therapeutic potential.

This compound's exploration contributes to our understanding of how targeted interventions can be made possible at the molecular level, propelling forward the field of drug development and personalized medicine.

Synonyms
o-Methylcarbanilic acid 3-quinuclidinyl ester
BRN 1474567
CARBANILIC ACID, o-METHYL-, 3-QUINUCLIDINYL ESTER
29440-71-9
RefChem:333135
Maybridge2_000464
SCHEMBL12604472
DTXSID80951960
HMS1304F02
1-Azabicyclo[2.2.2]octan-3-yl hydrogen (2-methylphenyl)carbonimidate