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Quinuclidine

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Identification
Molecular formula
C7H13N
CAS number
100-76-5
IUPAC name
quinuclidine
State
State

At room temperature, quinuclidine is typically found in a solid state.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.20
Boiling point (Celsius)
148.50
Boiling point (Kelvin)
421.60
General information
Molecular weight
129.21g/mol
Molar mass
129.2080g/mol
Density
1.0000g/cm3
Appearence

Quinuclidine appears as a white crystalline solid. It is known for its distinct, strong odor.

Comment on solubility

Solubility of Quinuclidine

Quinuclidine, with the chemical formula C7H13N, exhibits interesting solubility characteristics that are important for various applications. Here are some key points regarding its solubility:

  • Polar Solvents: Quinuclidine is known to be soluble in polar solvents like water, although its solubility may not be extremely high compared to other compounds.
  • Non-Polar Solvents: It shows a better solubility profile in non-polar organic solvents, such as ethanol and chloroform, due to its hydrophobic nature.
  • Influence of Temperature: The solubility of quinuclidine can be enhanced with an increase in temperature, making it more soluble in both polar and non-polar solvents at elevated conditions.
  • pH Sensitivity: Changes in pH can also affect the solubility of quinuclidine, as it may form protonated species that have differing solubility characteristics.

In summary, the solubility of quinuclidine could be described as moderately soluble in polar solvents and more so in organic solvents. Its solubility dynamics make it a versatile compound in chemical processes.

Interesting facts

Intriguing Insights into Quinuclidine

Quinuclidine, a fascinating bicyclic amine, has attracted attention both in the realm of organic chemistry and pharmacology. Its unique structure, characterized by a nitrogen-containing five-membered ring fused to a six-membered ring, lends it a range of interesting properties and applications.

Key Highlights

  • Structural Uniqueness: The bicyclic nature of quinuclidine contributes to its distinctive reactivity, making it a valuable building block in organic synthesis.
  • Versatile Intermediary: Quinuclidine acts as an intermediary in various chemical reactions, serving roles in synthesizing different compounds, including pharmaceuticals.
  • Pharmacological Significance: It has been investigated for its potential applications in drug development, particularly in areas such as cognitive enhancement and neuroprotective therapies.
  • Team Player: Quinuclidine readily forms salts and derivatives, enhancing its solubility and bioavailability—traits that are often desirable in medicinal chemistry.

As a chemistry student, you might find quinuclidine's ability to act as a ligand in coordination chemistry particularly compelling. Its nitrogen atom can coordinate with metals to form complexes, which could be useful in catalysis and material science. Furthermore, quinuclidine's chiral derivatives are pivotal in asymmetric synthesis, allowing for the production of enantiomerically pure compounds.

In the words of a noted chemist, "The true beauty of quinuclidine lies in its potential—unlocking doors to new medicinal pathways and innovative syntheses." Whether you're delving into theoretical studies or practical applications, quinuclidine undoubtedly presents a myriad of opportunities for exploration.

Synonyms
QUINUCLIDINE
100-76-5
1-Azabicyclo[2.2.2]octane
1,4-Ethanopiperidine
1,4-Ethylenepiperidine
Chinuclidin
1-Azabicyclo(2.2.2)octane
ABCO
4-Azabicyclo[2.2.2]octane
UNII-XFX99FC5VI
XFX99FC5VI
EINECS 202-887-1
MFCD00006690
DTXSID2057607
CHEBI:38420
QUINUCLIDINE [MI]
CHEMBL1209648
DTXCID0031396
NSC-168431
quinuclidine,1-Azabicyclo[2.2.2]octane
4-Azabicyclo(2.2.2)octane
1-azabicyclo(2.2.2)octane;quinuclidine
1-azabicyclo[2.2.2]octane;quinuclidine
azabicyclo[2.2.2]octane
Quinuclidines
Quinuclidine, 97%
SCHEMBL18960
1-azabicyclo[2,2,2]octane
1-Azoniabicyclo[2.2.2]Octane
SCHEMBL11328296
SCHEMBL25118167
Tox21_113847
BDBM50416495
PDSP1_000405
PDSP2_000403
AKOS015840987
CS-W013663
NCGC00253728-01
AS-31127
CAS-100-76-5
SY046764
DB-007846
NS00023002
Q0062
SR-01000944922
Q1864086
SR-01000944922-1
BRD-K84257395-001-01-1
202-887-1