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Hydroxychloroquine

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Identification
Molecular formula
C18H26N2O
CAS number
118-42-3
IUPAC name
(R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol
State
State

At room temperature, hydroxychloroquine is found in the solid state, typically as a crystalline powder.

Melting point (Celsius)
240.00
Melting point (Kelvin)
513.20
Boiling point (Celsius)
531.40
Boiling point (Kelvin)
804.60
General information
Molecular weight
335.87g/mol
Molar mass
335.8720g/mol
Density
1.3600g/cm3
Appearence

Hydroxychloroquine is typically a white or off-white crystalline powder. It is odorless and has a bitter taste.

Comment on solubility

Solubility of (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol

The solubility of (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol can be influenced by various factors including its molecular structure, polarity, and the presence of functional groups. Here are some key points regarding its solubility characteristics:

  • **Polarity**: This compound exhibits both polar and nonpolar characteristics due to its ethoxy group and quinoline structure, which can affect solubility in different solvents.
  • **Solvent Compatibility**: It is expected to have better solubility in organic solvents such as ethanol and methanol due to the presence of the ethoxy moiety.
  • **Hydrogen Bonding**: The presence of the methanol group suggests that it may engage in hydrogen bonding, potentially enhancing its solubility in polar solvents.
  • **Temperature Dependence**: Solubility may increase with temperature, thus solubility tests should be conducted at various temperatures for accurate assessment.
  • **pH Sensitivity**: The solubility could also be pH-dependent due to functional groups that may ionize at different pH levels, leading to varying solubility profiles.

In summary, while an exact prediction of solubility requires experimental data, understanding the structural attributes can provide valuable insights into its potential behavior in various solvent systems. As with many complex organic compounds, it is important to consider the context of solubility based on specific applications.

Interesting facts

Interesting Facts About (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol

This compound is a fascinating example of how chemistry can intersect with pharmacology and medicinal applications. It holds potential implications in the development of new therapeutic agents, particularly in the field of antipsychotics and neurological treatments. Here are some intriguing points to consider:

  • Stereochemistry: It showcases a well-defined stereochemistry with multiple chiral centers, notably impacting its biological activity and interactions within the body.
  • Quinolyl Group: The presence of the quinolyl moiety contributes to the compound’s capability to interact with a variety of biological targets, enhancing its potential efficacy in drug development.
  • Quinuclidinyl Functional Group: The unique quinuclidine structure provides a platform for the selective inhibition of certain receptors, highlighting the importance of molecular geometry in pharmacology.
  • Therapeutic Potential: Preliminary studies suggest that compounds like this may influence neurotransmitter systems, particularly those related to dopamine and serotonin, which are vital in treating mood disorders and schizophrenia.
  • Research Interest: The compound has garnered attention in academic and pharmaceutical research, leading to ongoing investigations into its safety, efficacy, and mechanism of action.

In conclusion, (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol exemplifies the complexity and beauty of chemical compounds. As researchers continue to explore its properties and potential applications, we could unlock innovative treatments that could have a profound impact on mental health and well-being.