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Quinine hydrochloride

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Identification
Molecular formula
C20H25ClN2O2
CAS number
Not available
IUPAC name
(R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol;hydrochloride
State
State

Quinine hydrochloride is solid at room temperature.

Melting point (Celsius)
172.00
Melting point (Kelvin)
445.15
Boiling point (Celsius)
220.00
Boiling point (Kelvin)
493.15
General information
Molecular weight
396.92g/mol
Molar mass
396.9200g/mol
Density
1.2800g/cm3
Appearence

Quinine hydrochloride appears as a white crystalline powder. It is often used in its salt form for medicinal purposes, particularly in the form of tablets or capsules that are ingested orally.

Comment on solubility

Solubility of (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol;hydrochloride

The solubility of the compound (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol; hydrochloride is influenced by various factors, characteristic of many organic compounds, particularly those with intricate structural frameworks.

Key considerations regarding its solubility include:

  • Polarity: The presence of functional groups within the molecular structure, such as the methanol and hydrochloride moieties, contributes to elevated polarity, enhancing solubility in polar solvents like water.
  • Hydrochloride salt formation: As a hydrochloride salt, it generally exhibits improved solubility compared to its free base form due to increased ionic character, which tends to favor aqueous solubility.
  • Temperature: Solubility often increases with temperature, meaning that heating the solvent may facilitate dissolving the compound better.
  • pH Levels: The solubility of hydrochlorides may vary with changes in pH, typically remaining soluble in acidic conditions while showing reduced solubility in basic environments.

It’s worth noting that while this compound is expected to demonstrate reasonable solubility in polar solvents, certain structural characteristics may limit its overall solubility in organic solvents or in particular aqueous systems. Thus, practical testing and examination of its solubility profile in various environments will yield the most accurate understanding of its behavior in solution.

Interesting facts

Overview of (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol; hydrochloride

The compound (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol; hydrochloride, often referred to simply as quinuclidine derivative, is a fascinating example of a complex organic molecule with significant implications in medicinal chemistry.

Key Characteristics

  • Pharmaceutical Applications: This compound is a key player in the development of novel drugs, particularly within the realm of CNS (central nervous system) disorders. Its unique structural features make it a promising candidate for neurological studies.
  • Synthesis: The synthesis of this compound involves intricate organic reactions, showcasing the art and science of organic chemistry. The use of quinuclidine moieties highlights the versatility of nitrogen-containing cyclic compounds in drug design.
  • Isomerism: This compound specifically exists in the R-enantiomer form, which is essential as the stereochemistry can dramatically influence biological activity and therapeutic efficacy.
  • Mechanism of Action: Compounds like this often act as modulators of neurotransmitter systems, impacting pathways involved in mood regulation, cognition, and other critical functions within the brain.

Research & Development

Current research is focusing on:

  • Characterizing interactions with dopamine and serotonin receptors, vital for developing treatments for depression and anxiety.
  • Exploring its potential in cognitive enhancement and neuroprotection.
  • Understanding its pharmacokinetics and metabolism, crucial for ensuring efficacy and safety in therapeutic applications.

As we continue to delve into the complexity of compounds like (R)-(6-ethoxy-4-quinolyl)-[(2S,5R)-5-ethyl-2,5-dimethyl-quinuclidin-2-yl]methanol; hydrochloride, it becomes clear that their potential in pharmaceutical development is vast and exciting. The journey of discovering how specific molecular configurations influence biological systems is an ongoing adventure in the world of chemistry.

Synonyms
D87818