Skip to main content

Halofantrine

ADVERTISEMENT
Identification
Molecular formula
C26H30ClNO2
CAS number
69756-53-2
IUPAC name
(R)-(6-methoxy-4-quinolyl)-[(2S,5R)-5-vinylquinuclidin-2-yl]methanol
State
State

At room temperature, halofantrine is typically a solid. This compound retains its stability under standard conditions.

Melting point (Celsius)
242.50
Melting point (Kelvin)
515.70
Boiling point (Celsius)
612.60
Boiling point (Kelvin)
885.80
General information
Molecular weight
480.06g/mol
Molar mass
480.0600g/mol
Density
1.1375g/cm3
Appearence

Halofantrine typically appears as a white to pale yellow crystalline powder. It is sparingly soluble in water but more soluble in organic solvents.

Comment on solubility

Solubility of (R)-(6-methoxy-4-quinolyl)-[(2S,5R)-5-vinylquinuclidin-2-yl]methanol

The solubility of (R)-(6-methoxy-4-quinolyl)-[(2S,5R)-5-vinylquinuclidin-2-yl]methanol is an essential aspect to consider in both chemical applications and pharmacological contexts. This compound encompasses several functional groups that influence its solubility characteristics.

Key Points on Solubility:

  • Polarity: The presence of a methanol group typically enhances solubility in polar solvents, but the overall structure's features can balance this effect.
  • Aromatic Characteristics: The quinolyl moiety may introduce hydrophobic traits, potentially lowering solubility in aqueous environments.
  • Interactions: Hydrogen bonding capabilities stemming from the methanol functionality can facilitate solubility in alcohols and potentially in water.

In summary, the solubility of this compound can be summarized as follows:

  1. Likely soluble in polar solvents due to methanol group.
  2. Potentially less soluble in purely aqueous solutions due to hydrophobic segments.
  3. Solubility may vary significantly with temperature and solvent composition.

Understanding these solubility characteristics is critical for applications in drug formulation and synthesis.

Interesting facts

Interesting Facts about (R)-(6-methoxy-4-quinolyl)-[(2S,5R)-5-vinylquinuclidin-2-yl]methanol

(R)-(6-methoxy-4-quinolyl)-[(2S,5R)-5-vinylquinuclidin-2-yl]methanol is a fascinating compound that highlights the intricate world of organic chemistry and pharmaceuticals. Here are some engaging aspects that make this compound noteworthy:

  • Chiral Center: This compound features specific stereochemistry with multiple chiral centers, enhancing its potential biological activity. Chirality is a crucial concept in drug design, as the different enantiomers of a compound can exhibit significantly different effects in biological systems.
  • Quinolyl Domain: The quinolyl moiety contributes to the compound's unique properties. Quinolines and their derivatives have been widely studied for their diverse biological activities, including antimalarial and anticancer effects, making quinolines a key focal point in medicinal chemistry.
  • Potential Applications: The design and synthesis of compounds like this one with both quinoline and quinuclidine structures can lead to the development of innovative pharmaceuticals. Their structure-activity relationship (SAR) can aid in creating new therapies targeting various diseases.
  • Research Interest: The synthesis and study of such specialized compounds continue to be an active area of research. Scientists are eager to explore the mechanisms by which these compounds exert their therapeutic effects—vital knowledge for improving drug efficacy and safety.

In summary, (R)-(6-methoxy-4-quinolyl)-[(2S,5R)-5-vinylquinuclidin-2-yl]methanol is not just another compound; it represents the intersection of molecular design and biological function. The continuous exploration of its properties may pave the way for novel medicinal applications and enhance our understanding of complex chemical interactions.

Synonyms
Quininae
quinine sulfate
SR-01000075160
NCGC00166281-01
Quinine (BAN)
Kinder Quinina (TN)
Lopac0_001029
MLS001304041
CHEMBL387326
SCHEMBL12310700
HMS2233L08
BDBM50411276
AKOS015955637
(R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
SMR000718748
C06526
D08460
EN300-20496209
SR-01000075160-1
SR-01000075160-12
(R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl](6-methoxyquinolin-4-yl)methanol