Skip to main content

Coenzyme A

ADVERTISEMENT
Identification
Molecular formula
C21H36N7O16P3S
CAS number
85-61-0
IUPAC name
S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 4-(3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanethioate
State
State

At room temperature, Coenzyme A exists as a solid. Its stability and appearance can shift with hydration, but it remains water-soluble and appears as a yellowish solid.

Melting point (Celsius)
122.00
Melting point (Kelvin)
395.15
Boiling point (Celsius)
769.15
Boiling point (Kelvin)
1 042.15
General information
Molecular weight
767.54g/mol
Molar mass
767.5310g/mol
Density
1.3700g/cm3
Appearence

Coenzyme A is a yellow, water-soluble compound. It typically appears in its crystalline solid state in its pure form. As a compound that is widely studied in biochemistry, it’s usually handled in a hydrated state.

Comment on solubility

Solubility of S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 4-(3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanethioate

The solubility of this complex compound, represented by the formula C21H36N7O16P3S, is a multifaceted aspect influenced by its intricate molecular structure. Here are some key points to consider:

  • Polarity: The presence of multiple hydroxyl groups and phosphate moieties increases the compound's polarity, which typically enhances solubility in polar solvents like water.
  • Hydrophobic Interactions: Conversely, the long hydrocarbon chains and hydrophobic structural portions may confer lower solubility in aqueous environments, potentially leading to partial solubility.
  • Stability: The stability of solute-solvent interactions might dictate whether the compound will dissolve effectively or precipitate out.
  • pH Dependence: The solubility could also be affected by the pH of the solution, particularly due to the acidic or basic nature of the functional groups present.

In essence, while the compound exhibits characteristics that may promote solubility due to its numerous functional groups, the overall solubility behavior is likely to be complicated by the interplay of hydrophilic and hydrophobic regions. Therefore, lab testing to ascertain the exact solubility parameters in various solvents is essential to understand its behavior in practical applications.

Interesting facts

Interesting Facts about S-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-2-hydroxy-3,3-dimethyl-butanoyl]amino]propanoylamino]ethyl] 4-(3,7,12-trihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanethioate

This compound, a complex molecule, showcases the intricate beauty of organic chemistry. It is notable for its multifunctional nature, serving as a combination of essential biological factors and synthetic components. Here are some fascinating aspects of this compound:

  • Biological Relevance: This compound contains elements associated with purines, which are critical components of nucleotides, the building blocks of DNA and RNA.
  • Phosphorylation Sites: The presence of multiple phosphoryl groups adds layers of regulatory potential, as phosphorylation is a common mechanism in cellular signaling pathways.
  • Structural Complexity: The compound boasts a sophisticated structure with various functional groups, such as amines, hydroxyls, and thioates, highlighting the diversity seen in biochemical compounds.
  • Therapeutic Potential: Compounds with similar structures often exhibit pharmacological effects; therefore, this particular structure could be of interest in drug design and discovery aimed at targeting specific biological pathways.
  • Natural Product Inspiration: Some components of this molecule are inspired by naturally occurring steroids and other bioactive metabolites, giving it potential for applications in natural product chemistry.

As a chemical scientist or chemistry student, one might ponder how such a compound can influence biochemical processes. It evokes thoughts on the mechanisms through which drugs interact with biological systems and the potential they hold for developing novel therapeutic agents.

Exploring such compounds forces us to consider the intricate interplay between chemistry and biology, emphasizing the importance of interdisciplinary research in the advancement of modern medicine.