Nitrofurantoin | Solubility of Things

Identification

Molecular formula

C₈H₆N₄O₅

CAS number

67-20-9

IUPAC name

S-[2-(diethylamino)ethyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carbothioate

State

At room temperature, nitrofurantoin is in a solid state. This pharmaceutical compound is generally stored in a dry place to prevent moisture-related decomposition.

Melting point (Celsius)

272.00

Melting point (Kelvin)

545.15

Boiling point (Celsius)

290.00

Boiling point (Kelvin)

563.15

General information

Molecular weight

238.22g/mol

Molar mass

238.2220g/mol

Density

1.4082g/cm³

Appearence

Nitrofurantoin is typically found as a yellow amorphous crystalline powder. It may have a faint odor and is slightly soluble in water, giving an orange-yellow solution. Under standard lighting conditions, it appears as an intense yellow solid.

Comment on solubility

Solubility of S-[2-(diethylamino)ethyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carbothioate

S-[2-(diethylamino)ethyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carbothioate is a compound with unique solubility characteristics influenced by its functional groups and molecular structure. When examining its solubility properties, consider the following key points:

Polar and Nonpolar Interactions: The presence of the diethylamino group suggests that the compound may interact favorably with polar solvents, such as water and alcohols.
Hydrophobic Character: The 5-nitro-2-furyl moiety introduces a nonpolar region, which can reduce its overall solubility in highly polar solvents.
Solvent Compatibility: Based on its structure, S-[2-(diethylamino)ethyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carbothioate is likely soluble in organic solvents such as ethanol, methanol, and dimethyl sulfoxide (DMSO).

In summary, while S-[2-(diethylamino)ethyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carbothioate may display moderate solubility in polar solvents, its effectiveness in nonpolar environments will vary. The balance of hydrophilic and hydrophobic characteristics plays a crucial role in determining how this compound interacts with different solvents.

Interesting facts

Interesting Facts about S-[2-(diethylamino)ethyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carbothioate

S-[2-(diethylamino)ethyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carbothioate is a fascinating compound that has garnered interest in various fields of research. Here are some interesting insights:

Biological Relevance: This compound has shown potential in pharmaceutical applications, particularly as a *possible chemotherapeutic agent*. Its structural features allow it to interact with biological systems in unique ways.
Isomerism: The compound is notable for exhibiting *chirality*, which can lead to significant differences in its biological activity. Chirality in drugs is a critical aspect that chemists study to refine medicinal efficacy.
Furyl moiety: The presence of the nitro-substituted furyl group in the structure is integral to its reactivity and pharmacological properties. This moiety is often associated with *enhanced bioactivity*, making it a valuable building block in drug design.
Potential Applications: Research on compounds containing isoxazole rings, such as this one, suggests applications range from agricultural chemicals to materials science, expanding its industrial relevance.
Structure-Activity Relationship (SAR): Understanding how structural modifications affect activity is a key focus in drug development. Each part of this compound’s structure can influence its effectiveness and safety profile.

In conclusion, S-[2-(diethylamino)ethyl] 5-methyl-3-(5-nitro-2-furyl)isoxazole-4-carbothioate represents a rich area of study in medicinal and organic chemistry. As scientists continue to explore its potential, this compound may pave the way for new therapeutic strategies.

Synonyms

4-Isoxazolecarbothioic acid, 5-methyl-3-(5-nitro-2-furyl)-, S-2-(diethylamino)ethyl ester

22996-68-5

5-Methyl-3-(5-nitro-2-furyl)-4-isoxazolecarbothioic acid S-2-(diethylamino)ethyl ester

DTXSID40177543