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Chlorambucil

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Identification
Molecular formula
C14H19Cl2NO2S
CAS number
305-03-3
IUPAC name
S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate
State
State

Chlorambucil is typically found in a solid state at room temperature. Its crystalline structure makes it suitable for storage in solid form under controlled laboratory settings.

Melting point (Celsius)
65.50
Melting point (Kelvin)
338.70
Boiling point (Celsius)
465.10
Boiling point (Kelvin)
738.30
General information
Molecular weight
304.28g/mol
Molar mass
304.2140g/mol
Density
1.3385g/cm3
Appearence

Chlorambucil appears as a yellowish-white crystalline powder. It is quite stable under ordinary conditions; however, direct exposure to light should be avoided to prevent degradation. Chlorambucil is not very soluble in water, but it is soluble in organic solvents.

Comment on solubility

Solubility of S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate

S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate is a compound that typically exhibits moderate solubility in organic solvents. Its structure, which features both aromatic and aliphatic components, suggests that its solubility properties might differ considerably in various environments. Here are some key points to consider:

  • Solvents: This compound is generally more soluble in organic solvents such as acetone, ethanol, and dimethyl sulfoxide (DMSO), while showing reduced solubility in polar solvents like water.
  • pH Influence: The solubility of S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate may be affected by the pH of the solution, especially due to the presence of amine functionalities that can undergo protonation.
  • Temperature Dependence: Like many other compounds, its solubility may increase with temperature, making heat application a potential method for improving dissolution rates.

To summarize, while S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate is not highly soluble in water, its solubility in organic solvents and the influence of external factors like temperature and pH give it a more versatile profile in chemical processes.

Interesting facts

Exploring S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate

S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate is a fascinating compound with notable significance in the realm of medicinal chemistry and pharmaceuticals. Its multifaceted structure gives it unique properties and potential applications. Here are some intriguing insights about this compound:

  • Versatile Applications: The compound is primarily recognized for its role in anticancer therapies. Its design enables targeting of cancer cells while minimizing effects on healthy cells, showcasing the importance of fine-tuning chemical structures for therapeutic efficacy.
  • Mechanism of Action: The presence of bis(2-chloroethyl) groups allows the compound to participate in alkylation reactions, damaging the DNA of cancer cells. This damage is critical for inhibiting their proliferation, making this compound a potential candidate in cancer treatments.
  • Innovation in Design: The incorporation of a thioate group enhances the overall reactivity of the compound, which can be manipulated to improve its pharmacological properties. This demonstrates how strategic modifications to chemical frameworks can lead to better therapeutic outcomes.
  • Research and Development: Ongoing studies on S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate explore its effects in combination therapies, enhancing its potential effectiveness against various types of tumors.
  • Safety and Efficacy: Understanding the compound's interaction with biological systems is crucial. Safety profiles and dose optimization are key areas of focus in the development pipeline, ensuring that it achieves desired outcomes without significant side effects.

In summary, S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate is more than just a chemical formula; it embodies the intersection of chemistry and medicine, showcasing the continuous innovation within the field. As researchers delve deeper into its capabilities, the potential for this compound to contribute significantly to therapeutic strategies remains promising.

Synonyms
1507-07-9
BRN 2811875
ACETIC ACID, THIO-, S-ESTER with 4-(BIS(2-CHLOROETHYL)AMINO)BENZENE THIOL
Acetic acid, thio-, S-(bis(2-chloroethylamino)phenyl ester
DTXSID00164595
4-13-00-01315 (Beilstein Handbook Reference)
DTXCID4087086
S-[4-[bis(2-chloroethyl)amino]phenyl] ethanethioate
CHEMBL3246925