Skip to main content

Quinidine Hydrochloride

ADVERTISEMENT
Identification
Molecular formula
C20H24ClN3O
CAS number
6108-05-0
IUPAC name
(S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol;hydrochloride
State
State
At room temperature, quinidine hydrochloride is in a solid crystalline form.
Melting point (Celsius)
230.00
Melting point (Kelvin)
503.15
Boiling point (Celsius)
370.00
Boiling point (Kelvin)
643.15
General information
Molecular weight
325.89g/mol
Molar mass
325.4450g/mol
Density
1.2300g/cm3
Appearence

Quinidine hydrochloride is typically encountered as a white or off-white crystalline powder. It is hygroscopic and may become sticky to the touch when exposed to a humid environment.

Comment on solubility

Solubility of (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol; hydrochloride

The solubility of the compound (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol; hydrochloride is an important characteristic that defines its behavior in both biological and chemical contexts. Here are some key points regarding its solubility:

  • Solvent Characteristics: This compound is likely to exhibit different solubility profiles in various solvents due to its functional groups, which include both polar and nonpolar regions.
  • Polar Solvents: Generally, compounds that possess ionic or polar functional groups tend to be more soluble in polar solvents like water. Given that this compound is a hydrochloride, it is expected to have a good solubility in aqueous solutions.
  • Nonpolar Solvents: In contrast, solubility in nonpolar solvents may be limited due to the presence of hydrophilic components which are less compatible with nonpolar environments.
  • Temperature Effects: The solubility can also vary with temperature; typically, an increase in temperature leads to increased solubility for most solid solutes.

To sum up, the solubility of (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol; hydrochloride can be anticipated to be higher in polar solvents, especially water, owing to the ionic nature of the hydrochloride form. A thorough understanding of its solubility is indispensable for its practical applications in research and pharmaceutical formulations.

Interesting facts

Interesting Facts about (S)-(6-Methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol Hydrochloride

This fascinating compound belongs to a class of chemicals known for their potential biological activities, particularly in medicinal chemistry. Here are some intriguing insights into its structure and possible applications:

  • Dual Functional Groups: The compound features both a quinoline and a quinuclidine moiety. Quinoline derivatives have been extensively studied for their antimicrobial and anti-cancer properties, while quinuclidine derivatives are known for their effectiveness in treating neurological disorders.
  • Stereochemistry Matters: The specific stereochemistry, namely the (S) and (2R,5R) configurations, plays a crucial role in the compound's biological activity. The orientation of the atoms can greatly influence how the compound interacts with biological targets, emphasizing the significance of chirality in drug design.
  • Plausible Therapeutic Uses: Preliminary studies suggest that compounds with similar structures may exhibit efficacy in treating conditions such as depression, anxiety, and even neurodegenerative diseases. This makes it a subject of interest for pharmaceutical research.
  • Research Challenges: The complex synthesis process and the need for high purity levels present challenges for researchers working with this compound. Determining optimal conditions for synthesis is vital to unlock its full potential.
  • Hydrochloride Form: The hydrochloride salt form of this compound may not only enhance its stability but also improve its solubility in aqueous solutions, making it easier for biological testing.

As science drives forward our understanding of chemical compounds, (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol hydrochloride stands as a promising candidate for further investigation. Future studies are likely to uncover more about its functionality and potential therapeutic roles, paving the way for new treatments.

Synonyms
DTXSID00937246
6'-Methoxycinchonan-9-ol--hydrogen chloride (1/1)