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Quinidine sulfate

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Identification
Molecular formula
C20H24N2O2·H2SO4
CAS number
6591-63-5
IUPAC name
(S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol;sulfuric acid
State
State

At room temperature, quinidine sulfate is found as a solid.

Melting point (Celsius)
0.00
Melting point (Kelvin)
0.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
782.96g/mol
Molar mass
782.9600g/mol
Density
1.2000g/cm3
Appearence

Quinidine sulfate typically appears as a white to off-white crystalline powder. It may have a slight aromatic odor.

Comment on solubility

Solubility of (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol in Sulfuric Acid

The solubility of (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol in sulfuric acid presents a complex interaction due to its unique molecular structure.

Key Aspects to Consider

  • Polarity: The presence of methoxy and quinuclidin groups in the structure may enhance the compound's polarity, potentially increasing its solubility in polar solvents like sulfuric acid.
  • Hydrogen Bonding: The hydroxyl (-OH) group in the methanol part of the compound can engage in hydrogen bonding with sulfuric acid, thus facilitating its dissolution.
  • Concentration Dependency: The extent of solubility may greatly depend on the concentration of sulfuric acid. Generally, a more concentrated acid can solvate organic molecules more efficiently.

It's crucial to note that solubility is a dynamic property that can be influenced by various factors, including temperature, pH, and the presence of other ions or solvents. Additionally, when discussing solubility in sulfuric acid, it is often crucial to consider both the physical state of the reactants and their reactivity under acidic conditions, as this may lead to unexpected results such as hydrolysis or structural changes.

In summary, while the overall solubility behavior of (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol in sulfuric acid can be anticipated to be relatively favorable due to the factors listed, experimental validation is recommended to precisely ascertain solubility limits and behavior.

Interesting facts

Interesting Facts about (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol with Sulfuric Acid

This sophisticated compound, which includes a quinoline moiety and a quinuclidine structure, is noteworthy in the realm of medicinal chemistry. Here are some interesting aspects to consider:

  • Complex Structure: The compound features unique structural elements such as the methoxy and vinyl groups, which can significantly influence its biological activity.
  • Potential Pharmacological Applications: Due to its quinoline framework, this compound has been studied for anti-malarial and anti-cancer properties, making it a critical compound for drug development.
  • Chirality: The (S) designation reflects its stereochemistry, which plays a crucial role in the compound's interaction with biological systems. Chirality can affect the potency and efficacy of drugs.
  • Reactivity with Acid: When sulfuric acid is used with this compound, it can lead to interesting reactions, possibly resulting in the formation of new derivatives that could be evaluated for enhanced pharmacological properties.
  • Research Implications: The study of this compound could pave the way for understanding the behavior of related molecules, giving insights into how modifications can lead to better therapeutic agents.

In summary, the multifaceted nature of (S)-(6-methoxy-4-quinolyl)-[(2R,5R)-5-vinylquinuclidin-2-yl]methanol combined with the dynamic influence of sulfuric acid makes it a compelling subject of study for chemists interested in drug design and development. As noted by researchers, “Understanding the intricate relationships between structure and activity can unlock the potential of compounds that may one day lead to new treatments.”

Synonyms
SCHEMBL1650841
AKYHKWQPZHDOBW-KYNMMFKBSA-N
(S)-[(2R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol;sulfuric acid