Indomethacin Sodium | Solubility of Things

Identification

Molecular formula

C₁₉H₁₅ClNNaO₄

CAS number

94540-13-9

IUPAC name

sodium;2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate

State

At room temperature, Indomethacin Sodium is a solid. It is stable under ordinary conditions of use and storage, but protection from moisture is recommended as it is hygroscopic.

Melting point (Celsius)

160.00

Melting point (Kelvin)

433.15

Boiling point (Celsius)

370.00

Boiling point (Kelvin)

643.15

General information

Molecular weight

412.85g/mol

Molar mass

412.8490g/mol

Density

1.4400g/cm³

Appearence

Indomethacin Sodium appears as an off-white to light yellow crystalline powder. It is practically odorless and has a bitter taste. It is sensitive to light, and its color may fade with exposure.

Comment on solubility

Solubility of Sodium 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate

The solubility of sodium 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate can be evaluated by considering various factors, as it is essential for its potential applications in pharmaceuticals and industrial processes.

Key Factors Influencing Solubility:

Polarity: Sodium salts typically exhibit higher solubility in polar solvents such as water compared to their neutral analogs due to ion-dipole interactions.
Temperature: An increase in temperature generally enhances the solubility of many compounds, including sodium salts.
pH Levels: As a compound that involves an indole moiety, its solubility may vary with pH, affecting the degree of ionization.
Presence of Other Ions: The solubility may also be influenced by the presence of other ions in solution, which can lead to potential precipitation or complex formation.

In many cases, the presence of the sodium ion enhances the solubility of the compound in aqueous solutions. As a rule of thumb, "the more polar a molecule, the greater its solubility in polar solvents." Thus, sodium 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate is likely to be relatively soluble in water, but its exact solubility would need to be determined experimentally.

Overall, understanding the solubility characteristics of this compound is crucial for predicting its behavior in biological systems and for its effective formulation in various chemical applications.

Interesting facts

Exploring Sodium 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate

Sodium 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate is a fascinating compound with a multitude of applications and intriguing properties. Here are some interesting facts about this chemical:

Pharmaceutical Potential: This compound is notable in the field of medicinal chemistry. It can serve as a lead for developing new pharmaceutical agents due to its unique structure that possibly enhances biological activity.
Molecular Structure: The compound features a complex indole structure, which is known for its diverse biological activities. Indoles often form the backbone of several important natural products and pharmaceuticals.
Substituent Influence: The presence of a 4-chlorobenzoyl group is significant as substituents can dramatically alter the compound's reactivity and interactions. Chlorinated aromatic compounds often exhibit enhanced pharmacological properties due to their increased lipophilicity.
Mechanism of Action: While specific mechanisms of action may currently be under investigation, indoles are known for interacting with various biological pathways, making this compound of particular interest for studying its potential therapeutic effects.
Research Applications: This compound's unique structure may also be leveraged for material science applications, such as in the design of organic semiconductors or conducting materials.

The intersection of this compound's structure and function illustrates the complex relationships between chemical composition and biological activity. As researchers delve deeper, we may uncover novel applications that could significantly impact medicine and materials science. Remember, as the due diligence of scientists continues, *the world of chemistry is ever-expanding*, and compounds like sodium 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-indol-3-yl]acetate are at the forefront of this exploration!