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Monensin Sodium

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Identification
Molecular formula
C36H61O11Na
CAS number
22373-78-0
IUPAC name
sodium;2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-tetrahydropyran-2-yl]-3-methyl-tetrahydrofuran-2-yl]-5-methyl-tetrahydrofuran-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyl-tetrahydropyran-2-yl]propanoate
State
State
Monensin sodium is generally available in a solid crystalline form at room temperature.
Melting point (Celsius)
268.00
Melting point (Kelvin)
541.15
Boiling point (Celsius)
205.00
Boiling point (Kelvin)
478.15
General information
Molecular weight
711.85g/mol
Molar mass
693.8720g/mol
Density
1.2700g/cm3
Appearence
Monensin sodium appears as a white or almost white crystalline powder. It is typically used as an antibiotic and ionophore in veterinary medicine, particularly in livestock feed.
Comment on solubility

Solubility of Sodium 2-[(3S,6R)-6-[[[5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-tetrahydropyran-2-yl]-3-methyl-tetrahydrofuran-2-yl]-5-methyl-tetrahydrofuran-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyl-tetrahydropyran-2-yl]propanoate

The solubility of this complex sodium salt can be influenced by various factors due to its intricate molecular structure. Key points to consider regarding its solubility include:

  • Polarity: The presence of multiple hydroxyl groups and ether linkages in the compound contributes to its polarity.
  • Hydrogen Bonding: The hydroxyl (-OH) groups facilitate hydrogen bonding, which may enhance solubility in polar solvents such as water.
  • Ionic Interaction: As a sodium salt, it is likely soluble in polar solvents due to the ionic nature of sodium, which can interact favorably with solvent molecules.
  • Temperature Effects: Solubility may increase with temperature, making it more soluble in hot solvents compared to cold.
  • Concentration Dependency: High concentrations may lead to saturation where solubility limits are reached, impacting the physical behavior of the compound.

In conclusion, while specific solubility data for this sodium salt might not be widely available, understanding the underlying molecular interactions provides a framework for predicting its behavior in various solvents. In general, compounds with such a robust and polar structure tend to showcase some level of solubility, especially in polar environments.

Interesting facts

Interesting Facts about Sodium; 2-[(3S,6R)-6-[[(5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-tetrahydropyran-2-yl]-3-methyl-tetrahydrofuran-2-yl]-5-methyl-tetrahydrofuran-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyl-tetrahydropyran-2-yl]propanoate

Sodium; 2-[(3S,6R)-6-[[[5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-tetrahydropyran-2-yl]-3-methyl-tetrahydrofuran-2-yl]-5-methyl-tetrahydrofuran-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyl-tetrahydropyran-2-yl]propanoate, commonly referred to by its IUPAC name, showcases a fascinating structure with multiple stereogenic centers which contributes to its intricate three-dimensional shape. Here are some noteworthy aspects:

  • Complexity of Structure: The compound reflects a high degree of stereochemistry, evident in the several chiral centers like those found at the 3S and 6R positions.
  • Biological Importance: Compounds like this can be of significant interest in pharmaceutical chemistry, potentially leading to the development of new drugs targeting specific biological pathways.
  • Applications: Investigating the biological activity of similar compounds often leads researchers to explore their use in medicinal chemistry, agricultural chemicals, and as potential therapeutic agents.
  • Synthesis Challenges: The multistep synthesis required to create this compound can present various challenges, often involving selective reactions and protection-deprotection strategies.
  • Structure-Activity Relationship (SAR): Understanding how structural variations affect activity is crucial in medicinal chemistry, making this compound a candidate for detailed SAR studies.

The study of compounds such as Sodium; 2-[(3S,6R)-6-[[[5R,6R,7R,9R)-2-[5-[(3S,5R)-5-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-tetrahydropyran-2-yl]-3-methyl-tetrahydrofuran-2-yl]-5-methyl-tetrahydrofuran-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyl-tetrahydropyran-2-yl]propanoate can lead to numerous exciting discoveries and innovations within the fields of chemistry and pharmacology, making it a prominent subject for ongoing research.