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Levothyroxine sodium

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Identification
Molecular formula
C15H10I4NNaO4
CAS number
25416-65-3
IUPAC name
sodium;(2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate
State
State

At room temperature, levothyroxine sodium is a solid.

Melting point (Celsius)
216.00
Melting point (Kelvin)
489.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
798.86g/mol
Molar mass
798.8590g/mol
Density
2.0000g/cm3
Appearence

Levothyroxine sodium appears as a white to off-white, odorless, tasteless crystalline powder.

Comment on solubility

Solubility of Sodium (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate

The solubility of sodium (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate can be characterized as follows:

  • Polar Nature: The presence of charged sodium ions paired with polar functional groups makes this compound likely to exhibit good solubility in polar solvents such as water.
  • Hydrogen Bonding: The hydroxyl groups in the structure can participate in hydrogen bonding with water molecules, enhancing its solubility.
  • Influence of Diiodo Groups: However, the presence of multiple iodine atoms may introduce steric hindrance and decrease solubility in certain organic solvents.
  • Environment Dependency: Factors such as pH and temperature can significantly affect the solubility of the compound, as changes can alter ionization states and, consequently, solubility.

In summary, one can anticipate that sodium (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate is likely to be soluble in polar solvents, particularly water due to its ionic and polar character, yet its solubility could vary under different environmental conditions.

Interesting facts

Interesting Facts about Sodium (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate

Sodium (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate is a fascinating compound with several intriguing characteristics:

  • Biological Relevance: This compound is often studied for its potential applications in pharmacology and biochemistry, particularly due to its complex structure which can interact with biological systems.
  • Structure Diversity: The presence of iodine atoms in the structure makes it particularly interesting; iodine is known for enhancing biological activity and stability in organic compounds.
  • Hydroxyl Groups: The compound features hydroxyl groups on its aromatic rings. These groups can influence the compound's reactivity and solubility, affecting how it interacts with other molecules.
  • Chirality: The compound contains a chiral center, making it one of the enantiomers of amino acids. This chirality can lead to different biological activities, which is a significant area of study in the field of medicinal chemistry.
  • Research Applications: It is believed that compounds like sodium (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate could play a role in drug development aimed at treating various health conditions, including cancers or hormonal disorders.

"Understanding the intricate nature of these compounds allows scientists to potentially unlock new avenues in therapeutic strategies and drug design."

In conclusion, sodium (2R)-2-amino-3-[4-(4-hydroxy-3,5-diiodo-phenoxy)-3,5-diiodo-phenyl]propanoate stands as an example of the complexity and potential that lies within organic chemistry, emphasizing the interplay between structure and function.