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Levothyroxine sodium

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Identification
Molecular formula
C15H10I4NO4Na
CAS number
55-03-8
IUPAC name
sodium;(2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate
State
State

Levothyroxine sodium is usually a solid at room temperature.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.00
Boiling point (Celsius)
336.00
Boiling point (Kelvin)
609.00
General information
Molecular weight
798.86g/mol
Molar mass
798.8590g/mol
Density
2.3285g/cm3
Appearence

Levothyroxine sodium typically appears as a light amber-brown, crystalline powder. It may exhibit a slight odor but is generally stable. Care should be taken as it is sensitive to air, light, and moisture, which can affect its stability.

Comment on solubility

Solubility of Sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate

The solubility of sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate, with the chemical formula C15H10I4NO4Na, can be considered from several angles:

  • Ionic Character: The presence of the sodium ion (Na+) typically enhances solubility in polar solvents, such as water.
  • Hydrophilicity: The compound's multiple functional groups, including a primary amine and hydroxyl groups, contribute to its overall hydrophilic nature, suggesting good solubility in polar media.
  • Iodine Substituents: The high iodine content can affect solubility. Iodinated compounds tend to be less soluble compared to their non-iodinated counterparts.

Generally, while one may expect a degree of solubility due to the ionic nature and polar functionality, the influence of iodine could counteract this effect, potentially leading to limited solubility in certain solvents. As a result, the solubility of this compound might vary significantly based on the formulation conditions and the choice of solvent.

In conclusion, the solubility of sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate is likely to be moderate, heavily influenced by the interplay between its ionic sodium content and the hydrophobic characteristics imparted by its iodine groups.

Interesting facts

Interesting Facts About Sodium (2S)-2-Amino-3-[4-(4-Hydroxy-3-Iodo-Phenoxy)-3,5-Diiodo-Phenyl]Propanoate

Sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate is a fascinating compound with intriguing properties and applications. Here are some compelling facts about this unique chemical:

  • Structure Insights: This compound showcases a complex structure featuring multiple iodine atoms, which is significant for its biological activity. Iodinated compounds often play critical roles in medical imaging and as pharmaceutical agents.
  • Pharmacological Potential: The presence of amino and hydroxy groups within its structure may enhance its solubility and ability to interact with biological systems. This makes it a candidate for drug development, particularly in targeting specific biological pathways.
  • Antioxidant Characteristics: Compounds that include phenolic groups, such as this one, may exhibit antioxidant properties, which are beneficial in protecting cells from oxidative stress.
  • Research Applications: The iodo-substituents can confer unique optical properties, making this compound useful in studies involving spectroscopic techniques as well as potential imaging applications in biochemistry.
  • Environmental Considerations: The iodine component raises questions about the environmental fate of such compounds, especially regarding their potential accumulation in ecosystems and bioaccumulation in living organisms.

In summary, sodium (2S)-2-amino-3-[4-(4-hydroxy-3-iodo-phenoxy)-3,5-diiodo-phenyl]propanoate presents a fascinating study of iodine chemistry and its implications in various fields such as medicinal chemistry, environmental science, and materials development. As research continues, the true potential of this compound may pave the way for novel therapeutic agents.