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Cloxacillin sodium

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Identification
Molecular formula
C19H17ClN3NaO5S
CAS number
7081-44-9
IUPAC name
sodium;(2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate
State
State
At room temperature, cloxacillin sodium is in a solid state.
Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
690.00
Boiling point (Kelvin)
963.15
General information
Molecular weight
476.88g/mol
Molar mass
476.8830g/mol
Density
1.4000g/cm3
Appearence

Cloxacillin sodium appears as a white to off-white crystalline powder. It is often seen as a hydrate form when used in clinical or laboratory settings.

Comment on solubility

Solubility Characteristics of Sodium (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; hydrate

The solubility of this compound in various solvents plays a significant role in its potential applications and behavior in different environments. Here are some key points regarding its solubility:

  • Water Solubility: The presence of the sodium ion typically enhances water solubility due to the ionic nature of salt formation. This compound, being a sodium salt, is generally expected to exhibit satisfactory solubility in aqueous solutions.
  • Organic Solvents: The organic components, especially the isoxazole ring and chlorophenyl groups, may influence solubility in organic solvents. It is likely to be soluble in polar organic solvents such as methanol or dimethyl sulfoxide (DMSO).
  • Temperature Dependency: Solubility often increases with temperature for salts like sodium compounds. Hence, this compound may exhibit higher solubility at elevated temperatures.
  • pH Influence: The ionization state of the compound can be affected by the pH of the solution, which might further influence its solubility.

In summary, the solubility of sodium (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; hydrate can be described as versatile, potentially soluble in both aqueous and select organic solvents, with factors such as temperature and pH playing a crucial role in its behavior.

Interesting facts

Interesting Facts about Sodium (2S,5R,6R)-6-[[3-(2-chlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; Hydrate

This compound is a unique example in the realm of organic chemistry, exhibiting a remarkable structure that integrates multiple functional groups, which can elevate its potential applications in various fields. Here are some intriguing aspects of this compound:

  • Complex Molecular Structure: The compound features a bicyclic framework, specifically a bicyclo[3.2.0]heptane structure, which is quite rare and intriguing for chemists. This complexity can lead to unique reactivity patterns.
  • Biological Significance: The presence of an isoxazole ring and a chlorophenyl group hints at potential biological activities. Compounds containing these moieties are often researched for their pharmacological properties, including anti-inflammatory and anti-cancer effects.
  • Potential Applications: Given its structure, this compound may serve as a lead compound in drug development. Researchers might be interested in its role as a novel antibiotic or antiviral agent due to its thiazolidine and oxo groups.
  • Hydrate Form: The hydrated form suggests it can interact with water, influencing its solubility and bioavailability. Understanding the hydration dynamics may enhance its formulation in pharmaceutical contexts.
  • Chirality Matters: With specific stereochemistry indicated (2S, 5R, 6R), the compound is chiral, which can lead to enantiomeric differences in efficacy and safety profiles that are crucial in drug development.

In summary, this compound is not only a testament to the complexity achievable in synthetic organic chemistry but also a potential cornerstone for future medicinal chemistry research. As scientists continue to explore its properties and applications, the fusion of unique functional groups and structural diversity may prove invaluable.