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Cloxacillin Sodium Hydrate

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Identification
Molecular formula
C19H16Cl2N3NaO5S · H2O
CAS number
7081-44-9
IUPAC name
sodium;(2S,5R,6R)-6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrate
State
State

At room temperature, cloxacillin sodium hydrate is in a solid state as a crystalline powder.

Melting point (Celsius)
175.00
Melting point (Kelvin)
448.00
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
499.94g/mol
Molar mass
499.9400g/mol
Density
1.3000g/cm3
Appearence

Cloxacillin sodium hydrate typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of Sodium (2S,5R,6R)-6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; hydrate

The solubility of this compound, commonly referred to as a sodium salt derivative, can be quite intricate due to its complex structure. Several factors influence its solubility, such as:

  • Polarity: The presence of polar functional groups, like the carboxylate and isoxazole moieties, typically increases solubility in polar solvents like water.
  • Ionic Nature: As a sodium salt, it tends to be more soluble in aqueous solutions, often dissociating into sodium ions and the associated anionic species.
  • Hydration: The hydrate form indicates the presence of water molecules, which can enhance solubility through solvation.
  • Temperature: Solubility may increase with temperature, allowing for more efficient dissolution of the compound in solution.

It is essential to note that while the sodium salt form is generally more soluble, the overall solubility will depend on the specific interactions between the compound and the solvent molecules. As stated in scientific literature, "The solubility of a compound can often determine its bioavailability and therapeutic effectiveness." Thus, understanding the solubility profile of this compound could be critical for its application in pharmaceutical formulations.

To summarize:

  • Higher polarity often leads to increased solubility.
  • The ionic nature enhances dissolution in water.
  • Temperature and hydration play significant roles.
Interesting facts

Interesting Facts about Sodium (2S,5R,6R)-6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; hydrate

This intriguing compound, often discussed within the realms of medicinal chemistry, is noteworthy for a variety of reasons. Not only does it contain a complex structure featuring a bicyclic system, but it also serves as an excellent example of how organic synthesis can lead to compounds with potential pharmacological applications.

Key Features

  • Pharmacological Potential: Derivatives of this compound have been researched for their therapeutic effects, particularly in the treatment of neurological disorders.
  • Complex Structure: The bicyclic formation allows for unique steric interactions, which can influence its biological activity significantly.
  • Functional Groups: The presence of isoxazole and thia functionalities contributes to the stability and reactivity of the compound, making it a subject of interest for further modifications.

The compound’s utilization of chlorine substitutions is particularly compelling as it often enhances the lipophilicity and biological activity. As chemists, we appreciate the fact that such modifications can lead to improved medicinal properties. Furthermore, the hydrate form exhibits different solubility characteristics that can affect its bioavailability and stability in pharmaceutical formulations.

Applications and Research

Current research is focused on:

  • Mechanism of Action: Studies are underway to elucidate how this compound interacts at the molecular level with biological targets.
  • Structure-Activity Relationship (SAR): Understanding how variations in the chemical structure influence efficacy and safety profiles.
  • Potential Use in Drug Development: The synthesis of similar compounds leads to a broader spectrum of pharmacological agents.

In conclusion, the ongoing exploration of Sodium (2S,5R,6R)-6-[[3-(2,6-dichlorophenyl)-5-methyl-isoxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate; hydrate continues to fuel scientific discovery, and its unique properties make it a valuable part of the chemical and pharmaceutical landscape.