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Ceftazidime

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Identification
Molecular formula
C22H22N6O7S2Na
CAS number
72558-82-8
IUPAC name
sodium;3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-[[2-(5-oxidooxadiazol-3-ium-3-yl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, Ceftazidime is typically in a solid state. It is provided in a sterile powder form suitable for reconstitution and use as an injectable medication in a clinical environment.

Melting point (Celsius)
205.00
Melting point (Kelvin)
478.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
636.58g/mol
Molar mass
636.5800g/mol
Density
1.7920g/cm3
Appearence

Ceftazidime typically appears as a white to cream-colored crystalline powder. It is highly soluble in water, making it practical for preparing solutions for intravenous or intramuscular injection. The compound is generally stored in sterile vials in a dry form for pharmaceutical use. Its appearance may slightly vary when hydrated or combined with other substances.

Comment on solubility

Solubility of Sodium; 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-[[2-(5-oxidooxadiazol-3-ium-3-yl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

The solubility of the compound sodium; 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-[[2-(5-oxidooxadiazol-3-ium-3-yl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate can be considered within the context of its complex structure. Factors affecting solubility include:

  • Polarity: The presence of ionic components and polar functional groups typically enhances solubility in water.
  • Functional Groups: With sulfonyl, thiadiazole, and carboxylate moieties, the compound may exhibit significant solubility in polar solvents.
  • Hydrogen Bonding: Potential for hydrogen bonding due to the various functional groups can further influence the solubility profile.

However, it's essential to note that the actual solubility can vary depending on the solvent used and the conditions such as temperature and pH. As with many complex organic compounds, empirical testing often provides the most accurate representation of solubility behavior. Thus, it is worth conducting specific experiments to understand the solubility in various conditions.

In summary, while theoretical insights can suggest desirable solubility characteristics, the unique molecular architecture of this compound warrants experimental validation to ascertain its true solubility in different environments.

Interesting facts

Interesting Facts about Sodium; 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-7-[[2-(5-oxidooxadiazol-3-ium-3-yl)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This compound is a remarkable example of the creativity present in modern chemical synthesis. It falls into a category known for its diverse applications, particularly in pharmaceuticals and biochemical research. Here are some engaging points about this compound:

  • Thiadiazole Structure: The presence of the thiadiazole ring in the compound is noteworthy. Thiadiazoles are known for their biological activities, including antimicrobial, antifungal, and anti-inflammatory properties, which make them valuable in drug development.
  • Multi-Functional Groups: This compound features various functional groups, such as an oxadiazole and a carboxylate, which contribute to its potential reactivity and interaction with biological macromolecules. Such structural diversity is key in medicinal chemistry.
  • Sodium Ion Role: The sodium component plays a crucial role in the solubility and stability of this compound. Sodium ions are often involved in biological processes, including nerve transmission and muscle contraction, which highlights the compound's potential for therapeutic applications.
  • Synthetic Versatility: Compounds like this one exemplify the effectiveness of combinatorial chemistry approaches, where various building blocks are assembled to create molecules with desired properties, enhancing the search for new drugs.
  • Research Potential: With increasing interest in heterocyclic compounds, this complex structure promises exciting opportunities for novel drug discovery, focusing on overcoming resistance in infectious diseases.

As a scientist or chemistry student, exploring compounds like this not only enhances your understanding of organic and medicinal chemistry but also inspires innovation in tackling global health challenges.