Skip to main content

Cefazoline Sodium

ADVERTISEMENT
Identification
Molecular formula
C14H13N8NaO4S3
CAS number
27164-46-1
IUPAC name
sodium;3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, cefazoline sodium is found in a solid state, usually in the form of powder or granules. It is stable under normal conditions and absorbs moisture from the air (hygroscopic).

Melting point (Celsius)
197.00
Melting point (Kelvin)
470.15
Boiling point (Celsius)
230.00
Boiling point (Kelvin)
503.15
General information
Molecular weight
476.49g/mol
Molar mass
476.4920g/mol
Density
1.7800g/cm3
Appearence

Cefazoline sodium is typically a white to off-white, crystalline powder. This compound may also appear as granules. Upon exposure to light, it can undergo discoloration, turning pale yellow, although this does not indicate decomposition as long as it has been stored properly.

Comment on solubility

Solubility of Sodium 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

The solubility of sodium 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is influenced by several factors, which can be summarized as follows:

  • Polarity: The presence of polar functional groups, such as the carboxylate and sulfur-containing moieties, enhances its solubility in polar solvents like water.
  • Ionic Nature: Being a sodium salt, it is expected to dissociate in solution, contributing to its overall solubility.
  • Temperature Effects: Typically, increasing temperature can increase the solubility of many salts in water.
  • pH Sensitivity: The solubility may vary with pH changes, which can affect the ionization of the compound.

Due to the diverse chemical structure, it is often noted that “solubility can vary widely depending on the specific conditions and the presence of other solutes.”
Therefore, experimental determination of solubility under various conditions is essential to fully understand its behavior in different environments.

Interesting facts

Interesting Facts about Sodium; 3-[(5-methyl-1,3,4-thiadiazol-2-yl)sulfanylmethyl]-8-oxo-7-[[2-(tetrazol-1-yl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This complex compound exemplifies the fascinating chemistry that can be achieved through the innovative combination of different molecular subunits. Often referred to in scientific circles as a bioactive drug candidate, it showcases various functionalities that make it an interesting subject for research. Some noteworthy points include:

  • Innovative Structure: The compound notably consists of a bicyclic framework, which is integral in many biological activities, allowing for unique interactions with target proteins.
  • Thiadiazole Moiety: The presence of the 5-methyl-1,3,4-thiadiazole ring adds a sulfur atom, which is critical in enhancing the compound’s pharmacological profile, often improving metabolic stability.
  • Tetrazole Ring: The incorporation of a tetrazole group not only contributes to the overall molecular rigidity but also significantly improves solubility and bioavailability.
  • Potential Applications: Compounds of similar composition have been studied for their possible applications as antibiotics and anti-inflammatory agents, highlighting their ability to inhibit bacterial growth and modulate immune responses.

Moreover, the intriguing functionalities that arise from this compound's diverse chemical groups solidify its place as a potential candidate for further research. As scientists continue to explore such intricate structures, they not only expand the knowledge of synthetic chemistry but also pave the way for new therapeutic agents.

The study of such compounds emphasizes the importance of multidisciplinary approaches that encompass organic chemistry, medicinal chemistry, and even pharmacology, showcasing the profound impact that innovative chemical design can have on human health.