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Cefotaxime

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Identification
Molecular formula
C16H16N5NaO7S2
CAS number
63527-52-6
IUPAC name
sodium;3-(acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
State
State

At room temperature, Cefotaxime sodium typically appears as a solid powder. It is stable under recommended storage conditions and is used in solution form for injections.

Melting point (Celsius)
167.00
Melting point (Kelvin)
440.15
Boiling point (Celsius)
780.00
Boiling point (Kelvin)
1 053.15
General information
Molecular weight
477.45g/mol
Molar mass
455.4370g/mol
Density
1.4605g/cm3
Appearence

Cefotaxime, in its sodium salt form, is typically a white to off-white powder. It is crystalline in nature and is highly soluble in water, which makes it suitable for intravenous or intramuscular administration as an antibiotic.

Comment on solubility

Solubility of Sodium 3-(Acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

The solubility of sodium 3-(acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate is a crucial characteristic that can influence its application in various fields, particularly in medicinal chemistry and pharmaceuticals. Here are essential points to consider regarding its solubility:

  • Sodium Salt Form: Being a sodium salt, this compound generally exhibits improved water solubility compared to its parent acid due to the ionic nature of sodium.
  • Polar Functional Groups: The presence of polar functional groups, such as carboxyl (-COOH) and acetoxy (-OCOCH3) moieties, typically enhances solubility in polar solvents, especially water.
  • pH Dependence: The solubility may vary with pH, as ionizable groups can behave differently depending on the acidity or basicity of the solution.
  • Complexation: The compound may also form complexes with various ions or molecules, potentially altering its solubility profile in different environments.

In summary, the solubility of sodium 3-(acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate can be considered generally favorable in aqueous solutions, influenced by factors such as ionic characteristics, polar functionalities, and environmental conditions. Understanding these factors is essential for its effective utilization.

Interesting facts

Interesting Facts about Sodium; 3-(Acetoxymethyl)-8-oxo-7-[[2-(3-pyridyl)acetyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

This compound is an intriguing example of medicinal chemistry, showcasing a blend of organic structures that hints at its potential therapeutic use. It contains a bicyclic framework known to produce significant biological activity, making it a subject of interest in drug design.

Key Features:

  • Unique Structure: The compound features a bicyclic skeleton that is characteristic of certain antibiotics, which can enhance its ability to interact with biological targets.
  • Functional Groups: The presence of both acetoxymethyl and pyridyl groups can modify the compound's reactivity and solubility, potentially leading to enhanced biological activity.
  • Biological Implications: This compound's acetyl and thioamide moieties suggest that it may exhibit antibacterial or antifungal properties, making it a candidate for further pharmacological studies.

According to researchers, compounds with similar structural motifs often show selective inhibition of specific enzymes or bacterial pathways. This ability to target precise sites within biological systems makes such compounds invaluable in the development of new pharmaceuticals.

In the quest for effective therapeutics, compounds like this one encapsulate the essence of chemical innovation and serve as a reminder of the intricate relationship between structure and function in medicinal chemistry. As ongoing studies explore its biological potential, this compound may pave the way for novel treatments in combating resistant pathogens.