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Tenofovir disoproxil

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Identification
Molecular formula
C19H30N5O10P
CAS number
201341-05-1
IUPAC name
sodium;[(3aR,4R,6R,6aR)-4-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate
State
State

At room temperature, tenofovir disoproxil is in the form of a solid.

Melting point (Celsius)
115.00
Melting point (Kelvin)
388.15
Boiling point (Celsius)
500.00
Boiling point (Kelvin)
773.15
General information
Molecular weight
519.40g/mol
Molar mass
519.4030g/mol
Density
1.4974g/cm3
Appearence

Tenofovir disoproxil is typically found as a white to off-white crystalline powder.

Comment on solubility

Solubility of Sodium;[(3aR,4R,6R,6aR)-4-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate

The solubility of sodium;[(3aR,4R,6R,6aR)-4-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl butanoate can be quite intriguing due to its complex structure. Understanding the solubility of this compound involves several key factors:

  • Polarity: The presence of polar functional groups, such as the ammonia and the phosphorus-containing dioxaphospholane, suggests that the compound may exhibit a degree of solubility in polar solvents.
  • Hydrogen bonding: The potential for hydrogen bonding due to the amino group and the carbonyl oxygen may enhance solubility in aqueous environments.
  • Hydrophobic character: The butanoyl and butanoate moieties could introduce hydrophobic characteristics, possibly affecting solubility in non-polar solvents.

In essence, while one might expect some degree of solubility in water due to its ionic sodium component and polar characteristics, the actual solubility can greatly vary based on the solvent used. As with many complex organic compounds, it can be said that:

“Solubility is dictated by a balance of intermolecular forces and the chemical nature of the solvent.”

Further experimental data would be necessary to ascertain the exact solubility profile of this compound in different solvents.

Interesting facts

Interesting Facts About Sodium [(3aR,4R,6R,6aR)-4-[6-(butanoylamino)purin-9-yl]-2-oxido-2-oxo-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-6-yl]methyl Butanoate

This compound, a fascinating sodium salt, belongs to a class of substances known for their potential in medicinal chemistry. Here are some intriguing points about it:

  • Complex Structure: The compound's intricate structure involves a fusion of multiple functional groups, particularly a purine base and a phospholanyl moiety, which contribute to its unique biological activity.
  • Biological Relevance: Compounds with purine structures are essential for life; they are the building blocks of nucleotides, which comprise DNA and RNA. The incorporation of amino groups enhances their functionality in biochemical processes.
  • Pharmacological Potential: Given its complex nature, there is ongoing research regarding its therapeutic effects, notably in fields such as anti-cancer and antibiotic research. It may act by modulating enzymatic pathways or inhibiting key cellular processes.
  • Role of Sodium: The inclusion of sodium is crucial as it often enhances the solubility and bioavailability of compounds, making them more effective in a biological context.
  • Versatile Applications: Potential uses may extend to various fields like drug formulation, gene delivery, and even in nanomedicine, where the compound's features could be harnessed for innovative treatments.

In conclusion, the sodium salt of this specific compound exemplifies the fascinating intersection of organic chemistry and pharmacology, illustrating the vast potential of complex molecules in developing new therapies and enhancing our understanding of biological systems.