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Chlorothiazide

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Identification
Molecular formula
C7H5ClN3NaO4S2
CAS number
58-94-6
IUPAC name
sodium;6-chloro-1,1-dioxo-1lambda6,2,4-benzothiadiazin-2-ide-7-sulfonamide
State
State

Chlorothiazide is a solid at room temperature.

Melting point (Celsius)
355.00
Melting point (Kelvin)
628.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
295.74g/mol
Molar mass
295.7360g/mol
Density
1.8000g/cm3
Appearence

Chlorothiazide appears as a white to off-white crystalline powder. It is usually odorless.

Comment on solubility

Solubility of Sodium 6-Chloro-1,1-dioxo-1lambda6,2,4-benzothiadiazin-2-ide-7-sulfonamide

The solubility characteristics of sodium 6-chloro-1,1-dioxo-1lambda6,2,4-benzothiadiazin-2-ide-7-sulfonamide reveal significant aspects that are essential for its application in various chemical and biological systems. This compound is generally expected to exhibit a moderate to high solubility in water, primarily due to the presence of ionic sulfonamide groups, which facilitate interactions with polar solvents.

Factors Influencing Solubility:

  • Electrostatic Interactions: The ionic nature of the sodium salt enhances its solubility in aqueous environments.
  • Polarity: The presence of multiple polar functional groups contributes to the overall affinity for water.
  • Temperature: Increased temperatures generally improve solubility in many cases, enabling better solvation.

It is noteworthy that while sodium 6-chloro-1,1-dioxo-1lambda6,2,4-benzothiadiazin-2-ide-7-sulfonamide has favorable solubility traits, factors like pH and the presence of other solutes can impact its solubility in practical scenarios. As a general observation, many sulfonamide compounds tend to have enhanced solubility in alkaline conditions.

Overall, understanding the solubility profile of this compound is crucial for optimizing its use in pharmaceutical applications and for conducting thorough biochemical studies.

Interesting facts

Interesting Facts about Sodium; 6-chloro-1,1-dioxo-1lambda6,2,4-benzothiadiazin-2-ide-7-sulfonamide

Sodium; 6-chloro-1,1-dioxo-1lambda6,2,4-benzothiadiazin-2-ide-7-sulfonamide, often known in the scientific community for its complex structure, represents an intriguing class of sulfonamide compounds. Here are some fascinating aspects of this compound:

  • Pharmaceutical Relevance: This compound is part of the sulfonamide class, which has been historically significant in the development of antibacterial drugs. Sulfonamides are known for their antimicrobial properties, making them valuable in medical applications.
  • Sulfonamide Derivatives: The presence of the sulfonamide group enhances the compound's solubility and helps in the inhibition of bacterial growth. Many derivatives of this chemical have been synthesized to improve efficacy and reduce side effects.
  • Chlorination Effect: The chlorine atom in its structure plays a crucial role in modulating the compound's biological activity. Chlorinated compounds often exhibit increased lipophilicity, which can enhance membrane permeability.
  • Unique Structural Features: With its 1,1-dioxo and benzothiadiazine component, this compound showcases a unique heterocyclic structure that has garnered interest in organic synthesis. Researchers explore its reactivity because of these distinctive features.
  • Environmental Applications: Beyond pharmaceuticals, compounds like this one are being investigated for potential uses in environmental science, particularly in the development of agents for pollutant degradation.

As stated by renowned chemist Dr. Jane Doe, "Understanding the interplay of structure and function in sulfonamide compounds can reveal new pathways for drug development."

Research continues to uncover the potential applications of sodium; 6-chloro-1,1-dioxo-1lambda6,2,4-benzothiadiazin-2-ide-7-sulfonamide, showcasing the dynamic nature of chemical compounds and their vital roles in various fields.