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Sulfamoyl chloride

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Identification
Molecular formula
H3ClNO2S
CAS number
13360-57-1
IUPAC name
sulfamoyl chloride
State
State

Sulfamoyl chloride is typically in a liquid state at room temperature.

Melting point (Celsius)
-10.00
Melting point (Kelvin)
263.15
Boiling point (Celsius)
166.00
Boiling point (Kelvin)
439.15
General information
Molecular weight
115.57g/mol
Molar mass
115.5700g/mol
Density
1.4790g/cm3
Appearence

Sulfamoyl chloride is a colorless to yellowish liquid. It is known for its pungent odor, which is typical of acyl chlorides. The compound is usually handled under inert atmosphere because it is sensitive to moisture.

Comment on solubility

Solubility of Sulfamoyl Chloride

Sulfamoyl chloride, with the chemical formula C1H6Cl1N1O2, exhibits notable solubility characteristics:

  • In Water: Sulfamoyl chloride is moderately soluble in water. Its solubility can vary with temperature and pH.
  • In Organic Solvents: It is soluble in a variety of organic solvents such as ethanol, acetone, and dichloromethane, making it versatile for different chemical reactions.
  • Reactivity with Water: When mixed with water, sulfamoyl chloride can react to produce hydrochloric acid and sulfamoyl amido compounds, which may affect its solubility.

In summary, the solubility of sulfamoyl chloride is influenced by its chemical structure, which allows for interactions with both polar and non-polar solvents. Understanding its solubility is essential when considering its applications in chemical synthesis, where the choice of solvent can significantly impact the outcome of reactions.

Interesting facts

Interesting Facts About Sulfamoyl Chloride

Sulfamoyl chloride, a versatile sulfonamide derivative, has garnered significant attention in the fields of organic synthesis and pharmaceuticals. As a functional group, sulfamoyl is integral to creating various biologically active compounds. Here are some intriguing details about sulfamoyl chloride:

  • Versatile Reactivity: Sulfamoyl chloride is known for its reactivity, particularly in forming sulfonamides. This makes it a valuable intermediate in the synthesis of pharmaceutical agents.
  • Biological Significance: Compounds derived from sulfamoyl chloride are often used in antibiotic medications, showcasing its essential role in medicinal chemistry.
  • Polymer Chemistry: Beyond pharmaceuticals, sulfamoyl chloride can serve as a monomer in the production of specialty polymers, enhancing material properties.
  • Safety Considerations: Like many chlorinated compounds, sulfamoyl chloride is hazardous and requires careful handling. It poses risks, including skin and respiratory irritation, necessitating proper safety protocols.
  • Moiety Importance: The sulfamoyl group itself plays a crucial role in biological activity, as it is involved in the mechanism of action of sulfa drugs, impacting enzyme activity and bacterial growth.

In summary, sulfamoyl chloride is not just a chemical compound; it's a fascinating building block for numerous applications in science. Its unique properties and interactions with other molecules continue to inspire ongoing research and innovation in chemistry and medicine.

Synonyms
Sulfamoyl chloride
7778-42-9
CHLOROSULFAMIC ACID
65MMZ8TWQ5
NSC 158265
NSC-158265
805-900-4
CHLOROSULFONAMIDE
Amidosulfonyl chloride
Aminosulfonyl chloride
Sulfamyl chloride
Chloroimidosulfuric acid
MFCD11519990
Amidosulfonic Acid Chloride
UNII-65MMZ8TWQ5
sulfamic chloride
chlorosulfonarnide
Sulphamoyl chloride
chlorosulfonyl amine
sulfamoy l chloride
Amidosulphonyl chloride
ClSO2NH2
H2NSO2Cl
NH2SO2Cl
DTXSID30228396
QAHVHSLSRLSVGS-UHFFFAOYSA-N
NSC158265
AKOS015900919
SY006415
CS-0008551
EN300-30440
Q27263894