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Betaxolol acetate

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Identification
Molecular formula
C18H29NO4
CAS number
90659-93-3
IUPAC name
tert-butyl-[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium;acetate
State
State

At room temperature, Betaxolol acetate is typically in a solid state. It is stable under normal conditions and is used primarily in pharmaceutical formulations which are often prepared in liquid form for ophthalmic use.

Melting point (Celsius)
159.00
Melting point (Kelvin)
432.15
Boiling point (Celsius)
313.40
Boiling point (Kelvin)
586.55
General information
Molecular weight
343.44g/mol
Molar mass
343.4390g/mol
Density
0.9683g/cm3
Appearence

Betaxolol acetate appears as a white to off-white powder. It is crystalline in nature and lacks a distinctive odor. It is generally provided in a solid form suitable for pharmaceutical applications.

Comment on solubility

Solubility of tert-butyl-[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium;acetate

The solubility of tert-butyl-[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium;acetate is influenced by several unique factors due to its complex structure. Being an ammonium compound, it tends to demonstrate a range of solubility behaviors depending on the solvent used:

  • Aqueous Solubility: It is generally water-soluble due to the presence of the ammonium group, which can interact with water molecules through hydrogen bonding.
  • Solvent Polarity: Solubility may vary with solvent polarity—polar solvents generally promote better solubility.
  • Temperature Dependence: Elevated temperatures can enhance solubility as the kinetic energy of molecules increases, allowing for better interaction with solvents.
  • pH Sensitivity: Solubility may also depend on the pH of the solution, affecting the ionization state of the ammonium moiety.

It is essential to note that due to the presence of hydroxyl groups in the aromatic segment, the compound can engage in additional hydrogen bonding, which may "compete" with interactions with the solvent; this can adjust its overall solubility characteristics. As noted, "the presence of functional groups such as -OH can be selective in their interactions". Therefore, when considering tert-butyl-[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium;acetate, one must take into account these factors to accurately predict its solubility in various environments.

Interesting facts

Interesting Facts about tert-butyl-[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium acetate

This compound is a fascinating example of how chemical modifications can enhance the properties of biological molecules. Often used in research to investigate cellular functions, its unique structure enables it to interact with various biological systems. Here are some intriguing aspects of this compound:

  • Biological Applications: The presence of the aromatic 3,4-dihydroxyphenyl group suggests that it may mimic neurotransmitters or other signaling molecules, making it a topic of interest in neurobiological studies.
  • Ammonium Group: The tert-butylammonium moiety enhances the solubility and stability in biological environments, enabling it to traverse lipid bilayers more effectively.
  • Potential Therapeutic Roles: Compounds featuring hydroxyl groups often exhibit antioxidant properties, which can play a crucial role in protecting cells from oxidative stress.
  • Synthetic Pathways: The synthesis of this compound involves interesting reactions that highlight the importance of each functional group in conferring specific characteristics to the final product.

Understanding and manipulating such compounds can lead to advancements in pharmacology and medicinal chemistry. As noted by renowned chemist Linus Pauling, "The nature of a chemical bond is the most important factor in determining the properties and reactivity of a molecule.” This is particularly true for compounds like tert-butyl-[2-(3,4-dihydroxyphenyl)-2-hydroxy-ethyl]ammonium acetate, where the interplay of functional groups can significantly influence its biological activity.


In conclusion, this compound stands as a remarkable intersection of chemistry and biology, with potential implications for developing new therapeutic agents and understanding complex biochemical pathways.