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Tamsulosin Hydrochloride

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Identification
Molecular formula
C20H28ClNO2
CAS number
106133-20-4
IUPAC name
tert-butyl-[2-hydroxy-3-(1-naphthyl)propyl]ammonium;chloride
State
State

The compound is typically a solid at room temperature, present in a crystalline form.

Melting point (Celsius)
234.00
Melting point (Kelvin)
507.15
Boiling point (Celsius)
210.00
Boiling point (Kelvin)
483.15
General information
Molecular weight
444.98g/mol
Molar mass
444.9800g/mol
Density
1.1000g/cm3
Appearence

Tamsulosin Hydrochloride appears as a white or almost white crystalline powder that is soluble in water and methanol.

Comment on solubility

Solubility of tert-butyl-[2-hydroxy-3-(1-naphthyl)propyl]ammonium chloride

The solubility of tert-butyl-[2-hydroxy-3-(1-naphthyl)propyl]ammonium chloride is a fascinating topic, particularly due to its unique structural features. As a quaternary ammonium salt, it exhibits certain characteristics in terms of solubility:

  • Apolar and Polar Solvents: This compound is typically more soluble in polar solvents such as water due to the presence of an ionic bond with the chloride ion. The polar -OH group contributes to this solubility, facilitating hydrogen bonding with water molecules.
  • Temperature Dependence: Solubility can be affected by temperature, with increased temperatures generally leading to increased solubility in water, aligning with common trends observed in salt-like compounds.
  • Influence of pH: The pH of the solvent can also influence solubility. In acidic conditions, the protonation state of functional groups could enhance solubility further.
  • Hydrophobic Interactions: The presence of the naphthalene ring adds hydrophobic character, which can limit solubility in non-polar solvents but may also suggest that it can behave differently in mixed solvents.

In conclusion, the solubility of tert-butyl-[2-hydroxy-3-(1-naphthyl)propyl]ammonium chloride exemplifies how structural features and solvent properties interplay. As noted, "the hydrophilic elements bolster solubility in polar environments while hydrophobic regions dictate behavior in non-polar media." Hence, understanding its solubility profile is essential in applications ranging from medicinal chemistry to materials science.

Interesting facts

Interesting Facts about tert-butyl-[2-hydroxy-3-(1-naphthyl)propyl]ammonium chloride

This fascinating compound, known as tert-butyl-[2-hydroxy-3-(1-naphthyl)propyl]ammonium chloride, is a quaternary ammonium salt that has garnered significant attention in the field of chemistry. Here are some intriguing facts about this compound:

  • Pharmaceutical Importance: Due to its unique structure, this compound may have potential applications in medicinal chemistry, particularly in drug formulation and delivery systems.
  • Versatile Interactions: The presence of both hydroxyl and naphthyl groups contributes to its capability to engage in various molecular interactions, including hydrogen bonding and π-π stacking.
  • Role in Catalysis: Compounds like this one can act as catalysts in organic reactions, potentially facilitating processes like alkylation and acylation, which are vital in synthetic organic chemistry.
  • Structure-Activity Relationship (SAR): Investigating the SAR for this compound can reveal how modifications to its structure influence biological activity, which is crucial for developing more effective therapeutics.
  • Environmental Impact: Understanding the behavior of quaternary ammonium compounds is essential, as they are often involved in applications ranging from industrial surfactants to biocides, raising questions about their environmental persistence and toxicity.

If you are intrigued by the world of organic compounds and their applications, exploring the properties and potential uses of tert-butyl-[2-hydroxy-3-(1-naphthyl)propyl]ammonium chloride can provide valuable insights. It exemplifies the intersection of structural chemistry and practical application, showcasing the creativity inherent in chemical research.

Synonyms
alpha-((tert-Butylamino)methyl)-1-naphthaleneethanol hydrochloride
1-NAPHTHALENEETHANOL, alpha-((tert-BUTYLAMINO)METHYL)-, HYDROCHLORIDE
22820-56-0
RefChem:1055972