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Tetrahydrofuran-3-ol

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Identification
Molecular formula
C4H8O2
CAS number
86087-23-2
IUPAC name
tetrahydrofuran-3-ol
State
State

At room temperature, tetrahydrofuran-3-ol is typically a liquid. Its low melting point allows it to remain in liquid form at typical ambient temperatures, contributing to its utility as a solvent.

Melting point (Celsius)
-58.00
Melting point (Kelvin)
215.15
Boiling point (Celsius)
179.20
Boiling point (Kelvin)
452.35
General information
Molecular weight
86.12g/mol
Molar mass
86.1320g/mol
Density
1.0750g/cm3
Appearence

Tetrahydrofuran-3-ol is a colorless liquid with a characteristic odor. It is often clear and can be miscible with water, making it a versatile solvent in various chemical reactions.

Comment on solubility

Solubility of Tetrahydrofuran-3-ol

Tetrahydrofuran-3-ol, known for its unique structure, exhibits interesting solubility properties that are largely influenced by its functional groups and molecular interactions. This compound is primarily soluble in a variety of solvents, making it a versatile substance in chemical processes. Here are some key points regarding its solubility:

  • Polar Solvents: Tetrahydrofuran-3-ol is highly soluble in polar solvents such as water, ethanol, and methanol due to the presence of the hydroxyl group (-OH), which facilitates hydrogen bonding.
  • Non-Polar Solvents: Although its solubility in non-polar solvents is considerably lower, the compound may still dissolve to some extent in substances like hexane or benzene, yet this is not the preferred solvation route.
  • Temperature Effects: Solubility often enhances with temperature; warming a solution can increase the amount of tetrahydrofuran-3-ol that can be dissolved in a solvent.

It is crucial to note that the solubility behavior of tetrahydrofuran-3-ol can vary based on concentration and the specific conditions of the solvent system. As such, when considering practical applications or conducting experiments, it is advisable to consult solubility charts or conduct preliminary tests to determine the most effective solvent mixture for achieving desired concentrations. Always remember, “like dissolves like” when assessing solubility scenarios!

Interesting facts

Interesting Facts about Tetrahydrofuran-3-ol

Tetrahydrofuran-3-ol, often referred to by its shorthand THF-3-ol, is a fascinating chemical compound that has captured the interest of scientists and researchers alike due to its unique properties. Here are some interesting aspects of this compound:

  • Structure and Reactivity: THF-3-ol is derived from tetrahydrofuran, a cyclic ether, and features an alcohol functional group that significantly influences its reactivity and interactions in various chemical processes.
  • Synthesis: It can be synthesized through various methods, including the selective reduction of furans or the hydroxylation of tetrahydrofuran. This versatility in synthesis makes it valuable for laboratory and industrial applications.
  • Applications: Due to its solvent properties and reactivity, THF-3-ol is commonly used in:
    • Organic synthesis as a building block
    • Pharmaceutical formulations
    • Polymer chemistry for creating complex materials
  • Biological Significance: Some studies suggest that derivatives of THF-3-ol may exhibit biological activity, which opens potential research avenues in medicinal chemistry and agrochemicals.
  • Environmental Impact: Its biodegradability is an important aspect that researchers consider, especially when evaluating the safety and impact of chemical substances on the environment.

In the realm of chemistry, the exploration of compounds like tetrahydrofuran-3-ol not only enhances our understanding of organic reactions but also paves the way for innovative applications that can benefit various fields. As scientists continue to study its properties and behaviors, we gain deeper insights into the world of chemical compounds.

Synonyms
3-HYDROXYTETRAHYDROFURAN
453-20-3
Tetrahydrofuran-3-ol
oxolan-3-ol
3-Furanol, tetrahydro-
Tetrahydro-3-furanol
Tetrahydro-furan-3-ol
3-Hydroxyoxolane
84976-47-6
EINECS 207-219-2
NSC 71875
BRN 0102545
AI3-28120
MFCD00005374
DTXSID20868947
2-Furanyl,tetrahydro-3-hydroxy-, (R)- (9CI)
5-17-03-00064 (Beilstein Handbook Reference)
NSC-71875
(S) 3-Hydroxytetrahydrofuran
S-3-Hydroxytetrahydrofuran
3Hydroxyoxolane
Tetrahydrofuran3ol
3-tetrahydrofuranol
NSC71875
tetrahydrofuran-4-ol
3Furanol, tetrahydro
3hydroxytetrahydrofuran
3-hydroxytetrahydofuran
3-hydroxytetrahydrofurane
3-hydroxy tetrahydrofuran
3-hydroxy-tetrahydrofuran
3-hydroxy tetrahydrofurane
3-hydroxy-tetrahydrofurane
racemic tetrahydrofuran-3-ol
Tetrahydrofuran, 3-hydroxy-
rac-3-hydroxy-tetrahydrofuran
3-furanol, tetrahydro-, (r)
4MA8Z6Y28L
(3RS)-3-Hydroxytetrahydrofuran
CHEMBL2287517
(+/-)-3-hydroxytetrahydrofuran
DTXCID10817000
BCP04605
BCP33373
CS-M0786
3-Hydroxytetrahydrofuran, (+/-)-
AKOS009157141
PB17096
PB24525
PB25950
SB10387
SY003096
SY003288
SY016904
DB-012663
DB-012671
DB-031092
H1331
NS00001466
NS00076945
(S)-Tetrahydrofuran-3-ol;(3S)-oxolan-3-ol
EN300-70362
3-Hydroxytetrahydrofuran, ReagentPlus(R), 98%
Q4634149
3-Hydroxytetrahydrofuran, Vetec(TM) reagent grade, 98%
F0001-1228
Z1124541349
207-219-2