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Thiazole

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Identification
Molecular formula
C3H3NS
CAS number
288-47-1
IUPAC name
thiazole
State
State

At room temperature, thiazole is in a liquid state. It is often used in research and industrial applications because of its stability and solubility in various organic solvents.

Melting point (Celsius)
-30.00
Melting point (Kelvin)
243.15
Boiling point (Celsius)
116.00
Boiling point (Kelvin)
389.15
General information
Molecular weight
85.12g/mol
Molar mass
85.1170g/mol
Density
1.1980g/cm3
Appearence

Thiazole is a pale yellow to colorless liquid with a distinct, pungent odor. Its clear liquid state allows for easy handling in chemical syntheses and laboratory settings.

Comment on solubility

Solubility of Thiazole

Thiazole, a heterocyclic compound featuring a five-membered ring with both sulfur and nitrogen atoms, exhibits unique solubility characteristics that are of interest in various scientific fields. Generally, the solubility of thiazole can be described as follows:

  • Solvent Dependence: Thiazole is known to be soluble in polar solvents, such as water, ethanol, and methanol. This solubility arises due to its ability to form hydrogen bonds.
  • Temperature Effects: As with many organic compounds, an increase in temperature often leads to an increase in solubility. Thus, heating thiazole in compatible solvents may enhance its dissolution.
  • pH Influence: The solubility of thiazole can vary with pH. In acidic conditions, the compound may form more soluble species, whereas basic conditions could potentially decrease its solubility.
  • Applications: The solubility properties of thiazole make it highly valued in pharmaceuticals and agrochemicals, where its ability to dissolve in biological fluids facilitates its effectiveness.

In summary, thiazole's solubility is influenced by factors such as solvent polarity, temperature, and pH, making it a compound of significant interest for both industrial and research applications. Understanding these interactions is essential for the effective utilization of thiazole in various chemical processes.

Interesting facts

Interesting Facts about Thiazole

Thiazole is an intriguing five-membered heterocyclic compound that has attracted considerable interest in various fields of chemistry due to its unique structure and versatile properties. Here are some fascinating aspects of thiazole:

  • Structural Composition: Thiazole features a nitrogen atom and a sulfur atom as part of its ring structure. This combination lends the compound its distinctive characteristics, making it an interesting subject for study.
  • Diverse Applications: Thiazole derivatives are widely utilized in the pharmaceutical industry. They are known for their effectiveness in treating numerous medical conditions. For instance, thiazole has been associated with:
    • Antimicrobial properties
    • Anti-inflammatory effects
    • Anti-cancer activities
  • Natural Occurrence: Thiazole is not only synthetically produced; it also occurs naturally in certain biomolecules. For example, it forms part of the structure of thiamine (Vitamin B1), which is essential for cellular metabolism in living organisms.
  • Reactivity: The presence of the nitrogen and sulfur atoms in thiazole enables it to participate in various chemical reactions, such as nucleophilic substitutions and cycloadditions. This reactivity is pivotal for chemists looking to synthesize new compounds.
  • Research Significance: Ongoing research is exploring thiazole's potential in developing new materials, such as dyes and polymer additives, highlighting how compounds like thiazole can bridge the gap between organic chemistry and material science.

In summary, thiazole is more than just a simple compound; it is a key player in diverse scientific domains, showcasing the importance of heterocycles in both nature and technology. As with many compounds, the profound connections between their structure and function continue to inspire and challenge chemists around the world.

Synonyms
THIAZOLE
288-47-1
1,3-Thiazole
Thiazoles
FEMA No. 3615
CCRIS 3205
EINECS 206-021-3
320RCW8PEF
BRN 0103852
CHEBI:43732
THIAZOLE [FHFI]
THIAZOLE [MI]
MFCD00005315
DTXSID2059776
4-27-00-00960 (Beilstein Handbook Reference)
thiazol
tz
UNII-320RCW8PEF
a thiazole
racemic thiazole
Thiazole-
Thiazole, 99%
5H-1,3-thiazole
1,3-Thiazole #
Thiazole, >=99%
CHEMBL15605
DTXCID4037875
CHEBI:48901
FEMA 3615
BCP27450
BBL027512
STL372725
AKOS005146301
CS-W001237
LOM
SY004510
CB7853436
DB-000360
NS00014391
T0185
EN300-22312
A819630
Q413426
206-021-3