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Thiazole-4-carbonitrile

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Identification
Molecular formula
C4H2N2S
CAS number
18829-54-6
IUPAC name
thiazole-4-carbonitrile
State
State

At room temperature, thiazole-4-carbonitrile exists as a solid. Its crystalline nature makes it stable under typical environmental conditions.

Melting point (Celsius)
50.00
Melting point (Kelvin)
323.15
Boiling point (Celsius)
312.50
Boiling point (Kelvin)
585.70
General information
Molecular weight
108.13g/mol
Molar mass
108.1310g/mol
Density
1.3032g/cm3
Appearence

Thiazole-4-carbonitrile typically appears as a pale yellow to off-white crystalline substance. Its solid form is characteristic and easily recognizable due to its unique shade and texture.

Comment on solubility

Solubility of Thiazole-4-carbonitrile

Thiazole-4-carbonitrile, represented chemically as C5H4N2S, exhibits unique solubility characteristics that can be quite intriguing. Understanding the solubility of this compound involves observing its interaction with various solvents:

  • Polarity: Thiazole-4-carbonitrile is a moderately polar molecule, which influences its affinity towards polar solvents.
  • Solvent Compatibility: This compound is generally soluble in polar organic solvents such as dimethyl sulfoxide (DMSO) and acetone, while showing limited solubility in non-polar solvents.
  • Temperature Dependence: Like many organic compounds, solubility can often increase with an increase in temperature, allowing for better dissolution in chosen solvents.
  • Effect of Functional Groups: The presence of the cyano (-C≡N) functional group contributes to its solubility profile, enabling it to participate in hydrogen bonding with suitable solvents.

In summary, the solubility of thiazole-4-carbonitrile is influenced by its chemical structure, interactions with solvents, and external conditions. This compound demonstrates that “like dissolves like” is a crucial principle in chemistry, serving as a guiding factor for predicting solubility behavior.

Interesting facts

Interesting Facts about Thiazole-4-carbonitrile

Thiazole-4-carbonitrile is a fascinating compound that sits at the intersection of organic chemistry and medicinal development. Here are some engaging highlights about this unique molecule:

  • Structure & Function: The compound features a thiazole ring, which is a five-membered heterocyclic compound containing sulfur and nitrogen. This structural characteristic greatly contributes to its reactivity and potential applications.
  • Biological Significance: Thiazole derivatives, including thiazole-4-carbonitrile, have been studied for their biological activities. They are known to possess various pharmacological effects, making them potential candidates in drug discovery.
  • Applications: Beyond pharmaceuticals, thiazole-4-carbonitrile may find use in agricultural chemistry, particularly in the development of pesticides and herbicides, thanks to its ability to inhibit certain biological targets.
  • Synthetic Pathways: The synthesis of thiazole-4-carbonitrile can involve multiple routes. One common method includes the reaction of carbon disulfide with the appropriate amine and malononitrile, showcasing the versatility of synthetic organic chemistry techniques.
  • Research Frontier: Novel derivatives and analogs of thiazole-4-carbonitrile are continuously being synthesized and studied. Researchers are particularly interested in modifying its structure to enhance specificity and efficacy in targeted biological applications.

As a compound with compelling chemical properties and significant biological implications, thiazole-4-carbonitrile demonstrates the profound role that organic compounds play in advancing scientific research and developing new technologies. As quoted by a notable chemist, "Every molecule has its story; it is our job to uncover it." This sentiment could not be more accurate when exploring the chemical narrative of thiazole-4-carbonitrile.

Synonyms
4-CYANOTHIAZOLE
1452-15-9
4-Thiazolecarbonitrile
UNII-F11233V4YM
DTXSID3027401
HSDB 5829
F11233V4YM
EINECS 215-919-4
DTXCID907401
4-THIAZOLECARBONITRILE [HSDB]
4Thiazolecarbonitrile
215-919-4
1,3-thiazole-4-carbonitrile
MFCD00137817
thiazole-4-carbonitrile
4-cyanothiazole, AldrichCPR
SCHEMBL446583
CHEMBL3182229
Tox21_301240
AKOS000803904
CS-W022172
NCGC00255314-01
DS-10713
SY019636
CAS-1452-15-9
DB-063593
NS00044802
EN300-106721
Q27277491
Z1079456078