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sulfolane

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Identification
Molecular formula
C4H8O2S
CAS number
126-33-0
IUPAC name
thiolane 1,1-dioxide
State
State

At room temperature, sulfolane is a liquid.

Melting point (Celsius)
28.00
Melting point (Kelvin)
301.15
Boiling point (Celsius)
285.00
Boiling point (Kelvin)
558.15
General information
Molecular weight
120.17g/mol
Molar mass
120.1730g/mol
Density
1.2610g/cm3
Appearence

In its pure form, sulfolane is a colorless liquid with a slight odor. It is commonly used as a solvent due to its ability to dissolve both polar and non-polar compounds. It is typically observed as a liquid at room temperature.

Comment on solubility

Solubility of Thiolane 1,1-Dioxide

Thiolane 1,1-dioxide, also known as sulfolane, is quite interesting when it comes to its solubility properties. Here are some key points about its solubility:

  • Polar Solvent: Thiolane 1,1-dioxide is a polar aprotic solvent, and as a result, it exhibits good solubility in water.
  • Organic Solvents: It is also soluble in many organic solvents, including ethanol, methanol, and acetone.
  • Miscibility: Sulfolane is fully miscible with water, which makes it unique among similar compounds.
  • Solvation Properties: Its ability to interact with both polar and nonpolar substances enhances its solvation properties.

As stated in many studies, "the presence of the sulfone group promotes strong dipole-dipole interactions," which further supports its solubility in various environments. Thiolane 1,1-dioxide is utilized in applications where its solubility characteristics can be leveraged, such as in chemical synthesis and extraction processes. The molecular structure contributes to its ability to dissolve diverse solutes effectively, establishing it as a versatile compound in both industrial and laboratory settings.

Interesting facts

Exploring Thiolane 1,1-Dioxide

Thiolane 1,1-dioxide, a compound with intriguing properties, is often discussed within the realms of organic and medicinal chemistry. This compound belongs to the class of sulfur-containing heterocycles and is characterised by its distinct chemical structure which includes a five-membered ring containing sulfur and oxygen atoms.

Key Features of Thiolane 1,1-Dioxide

  • Versatile Reactivity: Thiolane 1,1-dioxide serves as an important intermediate in organic synthesis, contributing to the formation of various complex molecules.
  • Biological Significance: Certain derivatives of this compound exhibit noteworthy biological activities, making them candidates for pharmaceutical applications.
  • Functional Properties: The presence of sulfur and oxygen atoms indicates potential for unique reactivity patterns, which can be exploited in developing new materials or catalysts.
  • Research Applications: Researchers often investigate thiolane 1,1-dioxide to better understand its interactions in biological systems and its potential roles in medicinal chemistry.

In the words of a notable chemist, "The study of sulfur compounds like thiolane 1,1-dioxide unveils a treasure trove of chemical possibilities," emphasizing the importance of this compound in both theoretical and practical applications. The ongoing research aims to unveil even more potential uses, specifically in creating effective drugs and other valuable chemicals.

As scientific knowledge progresses, thiolane 1,1-dioxide remains a beacon of innovation, attracting attention to its versatile traits and underscoring the limitless exploration of chemistry.

Synonyms
SULFOLANE
126-33-0
Tetramethylene sulfone
Tetrahydrothiophene 1,1-dioxide
Sulfolan
Thiophene, tetrahydro-, 1,1-dioxide
1,1-Dioxothiolan
Sulpholane
thiolane 1,1-dioxide
Sulfalone
Sulphoxaline
Dioxothiolan
Thiophan sulfone
Bondelane A
Bondolane A
Thiophane dioxide
Thiacyclopentane dioxide
Cyclotetramethylene sulfone
Tetrahydrothiophene dioxide
Dihydrobutadiene sulfone
Thiolane-1,1-dioxide
Cyclic tetramethylene sulfone
1,1-Dioxidetetrahydrothiophene
Dihydrobutadiene sulphone
1,1-Dioxidetetrahydrothiofuran
Tetrahydrothiophene 1-dioxide
Thiocyclopentane-1,1-dioxide
2,3,4,5-Tetrahydrothiophene-1,1-dioxide
DTXSID3027037
Y5L06AH4G5
CHEBI:74794
NSC-46443
DTXCID407037
RefChem:889578
204-783-1
MFCD00005484
NSC 46443
Tetrahydrothiofen-1,1-dioxid
thiolane-1,1-dione
1-Thiolane-1,1-dione
Bondelane A; Bondolane A; Cyclic tetramethylene sulfone; Cyclotetramethylene sulfone; NSC 46443
CCRIS 2310
HSDB 122
tetrahydro-thiophene-1,1-dioxide
EINECS 204-783-1
Tetrahydrothiofen-1,1-dioxid [Czech]
1??-thiolane-1,1-dione
BRN 0107765
sulpholan
UNII-Y5L06AH4G5
1lambda6-thiolane-1,1-dione
AI3-09541
tetramethylenesulfone
tetramethylene sufone
tetramethylenesulphone
Sulfolane, 99%
tetramethylene-sulfone
tetramethylene sulphone
tetramethylene-sulphone
TETRAHYDROTHIOPHENE-1,1-DIOXIDE
Thiophane 1,1-dioxide
SULFOLANE [MI]
SULFOLANE [HSDB]
WLN: T5SWTJ
EC 204-783-1
SULFOLANE [USP-RS]
SCHEMBL14301
SCHEMBL30807
SCHEMBL42815
5-17-01-00039 (Beilstein Handbook Reference)
SCHEMBL181154
SCHEMBL449201
Sulfolane, analytical standard
Tetrahydothiophene-1,1-dioxide
tetrahydrothiophen-1,1-dioxide
tetrahydrothiophene-S,S-dioxide
SCHEMBL6406072
1,1-Dioxide tetrahydrothiofuran
CHEMBL3186899
(CH2)4SO2
Sulfolane, redistilled from glass
tetra-hydrothiophene-1,1-dioxide
Tetrahydrothiophene, 1,1-dioxide
MSK15601
NSC46443
Thiophene, 1,1-dioxide-tetrahydro-
Tox21_200628
SBB057389
STL268898
AKOS002676003
AKOS015955444
Residual Solvent Class 2 - Sulfolane
Sulfolane, purum, >=98.0% (GC)
FS32813
Sulfolane (Assay dry basis min 99.5%
2,4,5-Tetrahydrothiophene-1,1-dioxide
NCGC00248771-01
NCGC00258182-01
CAS-126-33-0
PS-11978
DB-038059
CS-0020029
NS00001349
ST50998869
T0115
EN300-18394
D78046
F044698
Q416239
F1294-0027
InChI=1/C4H8O2S/c5-7(6)3-1-2-4-7/h1-4H
QXB