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Thiophene-2-carboxylic acid

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Identification
Molecular formula
C5H4O2S
CAS number
527-72-0
IUPAC name
thiophene-2-carboxylic acid
State
State

Thiophene-2-carboxylic acid is a solid at room temperature. It maintains its powdery crystalline form, and remains stable under normal handling and storage conditions.

Melting point (Celsius)
143.00
Melting point (Kelvin)
416.00
Boiling point (Celsius)
252.00
Boiling point (Kelvin)
525.00
General information
Molecular weight
126.15g/mol
Molar mass
126.1480g/mol
Density
1.3550g/cm3
Appearence

Thiophene-2-carboxylic acid typically appears as a light cream to beige crystalline powder. It can sometimes appear whitish when in very pure form. The crystalline structure is often fine and powdery, lending it a slightly coarse texture.

Comment on solubility

Solubility of Thiophene-2-carboxylic Acid

Thiophene-2-carboxylic acid, with the chemical formula C5H4O2S, is a fascinating compound when it comes to its solubility characteristics. Understanding solubility is vital for applications in various fields including pharmaceuticals and material science.

General Solubility Behavior

In general, the solubility of thiophene-2-carboxylic acid can be described as follows:

  • Polar solvents: It is expected to be soluble in polar solvents like water due to the presence of the carboxylic acid functional group
  • Non-polar solvents: Its solubility tends to decrease in non-polar solvents, owing to the hydrophobic nature of the thiophene ring

Factors Influencing Solubility

Several factors affect its solubility, including:

  • Temperature: Increased temperature generally enhances solubility in many solvents
  • pH levels: The ionization of the carboxylic acid group can impact solubility, making it vary across different pH environments
  • Interactions: Hydrogen bonding with solvent molecules can significantly influence solubility

In conclusion, thiophene-2-carboxylic acid exhibits an interesting solubility profile, highlighting the complexities of solubility in organic compounds. The interplay between its hydrophilic and hydrophobic aspects marks it as a unique compound in the field of chemistry.

Interesting facts

Interesting Facts about Thiophene-2-Carboxylic Acid

Thiophene-2-carboxylic acid is a fascinating organic compound that captures the interest of chemists due to its unique structure and properties. Here are some key highlights:

  • Functional Group: The compound belongs to a class of compounds known as carboxylic acids, characterized by the presence of the carboxyl group (-COOH). This functional group is responsible for many of the acid's chemical behaviors.
  • Role in Synthesis: Thiophene-2-carboxylic acid serves as a crucial building block in organic synthesis. It is often used in the preparation of more complex compounds, including pharmaceuticals and agrochemicals.
  • Biochemical Significance: The presence of a thiophene ring in its structure may impart biological activity. Thiophene derivatives have been investigated for potential applications in medicinal chemistry, particularly as anti-inflammatory and antimicrobial agents.
  • Environmental Relevance: Thiophene-2-carboxylic acid can be produced from materials derived from plants, aligning with the growing interest in sustainable and green chemistry. Its utilization reflects the possibility of developing eco-friendly chemical processes.
  • Polymer Chemistry: This compound can participate in various polymerization reactions, paving the way for innovative materials with unique electronic and mechanical properties.

Overall, thiophene-2-carboxylic acid embodies a blend of organic structure and versatility, making it a subject of ongoing research and interest among scientists. As one might say, "the world of chemistry is truly enriched by exploring the vast potential of compounds like thiophene-2-carboxylic acid!"

Synonyms
2-Thiophenecarboxylic acid
527-72-0
2-Thenoic acid
2-Carboxythiophene
2-Thienylcarboxylic acid
Tenoic acid
2-TCA
Thenoic acid
NSC 2188
EINECS 208-423-4
Rhinotrophyl (TN)
BRN 0110150
Tenoic acid (DCF)
AI3-16118
NSC-2188
Thiophene-2-carbixylic acid
THENOIC ACID [WHO-DD]
DTXSID2060177
5-18-06-00158 (Beilstein Handbook Reference)
2-THIOPHENECARBOXYLIC ACID [MI]
Rhinotrophyl
2Carboxythiophene
2Thenoic acid
2Thiophenic acid
Thiophene2carboxylate
2Thienylcarboxylic acid
Thiophene2carboxylic acid
alphaThiophenecarboxylic acid
DTXCID7041259
208-423-4
THIOPHENE-2-CARBOXYLIC ACID
2-Thiophenic acid
alpha-Thiophenecarboxylic acid
MFCD00005437
.alpha.-Thiophenecarboxylic acid
2-thiophene carboxylic acid
Thiophene Carboxylic Acid
3FD00JX53J
CHEMBL1222314
CHEBI:71241
2-Thiophenecarboxylicacid
thiolcarboxylic acid
C5H4O2S
Thiophene-2-carboxylicAcid
UNII-3FD00JX53J
thienoic acid
THIOPHENECARBOXYLIC ACID
2-thienoic acid
2hdq
2-Thiophenecarboxylic Acid; 2-Carboxythiophene; 2-Thiophenic Acid; NSC 2188; alpha-Thiophenecarboxylic Acid
thiophencarboxylic acid
thienyl carboxylic acid
thiopene-2-carboxylic acid
thiophen-2-carboxylic acid
bmse000848
2-thiophene-carboxylic acid
NCIOpen2_000991
SCHEMBL83000
BIDD:GT0592
NSC2188
BCP15028
BDBM50324678
STK362877
AKOS000119344
AC-4922
BS-3764
CS-W020070
FT62260
NCGC00188253-01
BP-20572
SY001476
DB-000869
NS00032580
T0218
Thiophene-2-carboxylic acid; 2-Thenoic acid
EN300-16724
D08568
D70571
2-Thiophenecarboxylic acid, ReagentPlus(R), 99%
AQ-738/40654023
Q2823319
F2191-0071
2-Thiophenecarboxylic acid, Vetec(TM) reagent grade, 98%