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Thioxanthone

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Identification
Molecular formula
C13H8OS
CAS number
492-22-8
IUPAC name
thioxanthen-9-one
State
State

Thioxanthone is a solid at room temperature. It maintains its solid state under standard atmospheric conditions and does not sublimate. As a solid, it is typically handled in its powder form which offers ease of measurement and mixing in industrial and laboratory applications.

Melting point (Celsius)
169.00
Melting point (Kelvin)
442.15
Boiling point (Celsius)
440.00
Boiling point (Kelvin)
713.15
General information
Molecular weight
212.28g/mol
Molar mass
212.2760g/mol
Density
1.2895g/cm3
Appearence

Thioxanthone is a pale yellow crystalline powder. It may appear slightly greenish under certain lighting due to its characteristic fluorescence. The solid form is typically homogeneous, free from visible impurities, and exhibits a bright coloration under ultraviolet light.

Comment on solubility

Solubility of Thioxanthen-9-one

Thioxanthen-9-one, with the chemical formula C13H8S, displays some interesting characteristics regarding its solubility:

  • Polar Solvents: Thioxanthen-9-one is generally insoluble in water, as its structure does not favor interactions with water molecules.
  • Organic Solvents: However, it is well-soluble in organic solvents such as ethanol, acetone, and dimethyl sulfoxide (DMSO), which can effectively dissolve it.
  • Solubility Trends: The solubility of thioxanthen-9-one tends to increase with the polarity of the solvent, demonstrating a significant preference for solvents that can disrupt its molecular structure.
  • Practical Implications: Understanding the solubility of thioxanthen-9-one is crucial for applications in medicinal chemistry and materials science, where solvent choice may significantly affect reactivity and the behavior of thioxanthen-like compounds.

In summary, while thioxanthen-9-one shows a distinct lack of solubility in polar solvents, its compatibility with various organic solvents makes it versatile for laboratory use. Knowledge of its solubility profile helps in designing experiments and formulating solutions where this compound is involved.

Interesting facts

Interesting Facts about Thioxanthen-9-one

Thioxanthen-9-one is a fascinating compound that belongs to the thioxanthene family, which is recognized for its unique structural and chemical properties. This compound has garnered interest for several reasons:

  • Structural Characteristics: Thioxanthen-9-one features a thioxanthene scaffold, which contributes to its stability and reactivity. The presence of the sulfur atom in its structure distinguishes it from similar carbon-only compounds.
  • Applications in Medicine: This compound is related to a class of *antipsychotic medications* known as thioxanthenes. These medications have been used in the treatment of schizophrenia and other mental health disorders, showing the therapeutic potential of thioxanthen-9-one.
  • Photochemical Properties: Thioxanthen-9-one exhibits interesting photochemical behavior, making it a candidate for applications in *photodynamic therapy (PDT)* and other light-activated treatments. These properties arise from its ability to absorb light and generate reactive species.
  • Chemical Reactivity: The compound can participate in various chemical reactions, such as nucleophilic substitution and addition reactions. This versatility allows for the synthesis of derivatives that can be tailored for specific applications in research and industry.

As stated by one researcher, “Exploring compounds like thioxanthen-9-one opens doors to innovative therapies and materials that can benefit multiple fields, from medicine to materials science.” This highlights the importance of understanding such compounds in advancing both scientific knowledge and practical applications.

In summary, thioxanthen-9-one is not just an ordinary compound; its unique properties and applications make it a significant focus of ongoing research and a subject of interest in the chemical and pharmaceutical communities.

Synonyms
Thioxanthen-9-one
Thioxanthone
9H-THIOXANTHEN-9-ONE
UNII-EOK1SAC304
EOK1SAC304
EINECS 207-749-4
NSC-15912
THIOXANTHONE [MI]
NSC-658181
DTXSID8060082
Thioxanthen9one
9Thioxanthone
9Oxothioxanthene
Thioxanthene9one
10Thioxanthone
9HThioxanthen9one
Thioxanthene, 9oxo
9HThioxanthene, 9oxo
THIOXANTHONE [INCI]
DTXCID0040674
inchi=1/c13h8os/c14-13-9-5-1-3-7-11(9)15-12-8-4-2-6-10(12)13/h1-8
yrhriqcwcfgueq-uhfffaoysa-n
492-22-8
Thiaxanthone
9-Thioxanthone
Thioxanthenone
Thioxanthene-9-one
Thiaxanthenone
Thiaxanthon
9H-Thioxanthene, 9-oxo-
10-Thioxanthone
9-Oxothioxanthene
Thioxanthene, 9-oxo-
MFCD00005066
NSC 15912
NSC 658181
CHEMBL83371
MLS002638459
NSC658181
9H-Thioxanthen-9-one (Thioxanthone)
9H-Thioxanthen-9-one; Metixene Hydrochloride Imp. B (EP); Thioxanthone; Metixene Hydrochloride Impurity B; Metixene Impurity B
Thioxanthen-9-one, 97%
SCHEMBL36332
cid_10295
SCHEMBL6916271
HMS3089H20
NSC15912
NSC54677
BDBM50059265
NSC-54677
AKOS001664685
FT02852
AC-15767
NCI60_020340
SMR000743848
SY036813
Thioxanthone, purum, >=97.0% (HPLC)
DB-051613
CS-0097787
NS00022234
T2351
F13552
EN300-1693738
AG-205/04512037
SR-01000504711
Q2421313
SR-01000504711-1
Z1509688798
Thioxanthone, European Pharmacopoeia (EP) Reference Standard