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Fluorometholone

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Identification
Molecular formula
C22H29F3NO
CAS number
426-13-1
IUPAC name
trimethyl-[3-(2,2,2-trifluoro-1,1-dihydroxy-ethyl)phenyl]ammonium
State
State

At room temperature, Fluorometholone is typically found as a solid. It can be formulated into various pharmaceutical preparations, such as eye drops, where it is suspended in a liquid form.

Melting point (Celsius)
228.00
Melting point (Kelvin)
501.15
Boiling point (Celsius)
404.80
Boiling point (Kelvin)
677.95
General information
Molecular weight
376.46g/mol
Molar mass
376.4600g/mol
Density
1.2800g/cm3
Appearence

Fluorometholone appears as a crystalline white powder in its pure form. It is also available in ophthalmic suspension formulations and can appear as a milky liquid when in solution form for these applications.

Comment on solubility

Solubility of Trimethyl-[3-(2,2,2-trifluoro-1,1-dihydroxy-ethyl)phenyl]ammonium

The solubility of the compound trimethyl-[3-(2,2,2-trifluoro-1,1-dihydroxy-ethyl)phenyl]ammonium, with the formula C22H29F3NO, can be quite intriguing due to its unique structure. Here are some insights:

  • Polar and Non-polar Interactions: The presence of the trifluoromethyl group contributes to a certain degree of polarity, while the organic hydrocarbon framework tends to be more non-polar. This duality can lead to:
    • *Enhanced solubility in polar solvents,*
    • *Limited solubility in non-polar solvents.*
  • Effect of Hydroxy Groups: The dihydroxyethyl group can further enhance solubility in water due to hydrogen bonding capabilities, making it more soluble than compounds lacking such functional groups.
  • Influence of Temperature: Like many organic compounds, solubility can be greatly affected by temperature changes, typically increasing at higher temperatures.
  • Application Considerations: Understanding the solubility behavior is crucial for applications such as drug formulation and environmental impact assessments, where aqueous solubility may dictate behavior and efficacy.

In summary, while the precise solubility will depend on specific conditions, it is clear that the structure of this compound provides a complex interplay of factors affecting its solubility profile. As always, experimental data should be consulted for definitive solubility values.

Interesting facts

Interesting Facts about Trimethyl-[3-(2,2,2-trifluoro-1,1-dihydroxy-ethyl)phenyl]ammonium

Trimethyl-[3-(2,2,2-trifluoro-1,1-dihydroxy-ethyl)phenyl]ammonium, often referred to by its longer name, is a fascinating compound that falls under the category of quaternary ammonium compounds. Here are some key points that make it notable:

  • Unique Structure: The compound contains a quaternary nitrogen atom, allowing it to exist in a cationic form, enhancing its solubility in polar solvents. This structural attribute gives it distinct chemical properties.
  • Fluorinated Features: The presence of fluorine atoms in its structure suggests a significant alteration in properties compared to non-fluorinated analogs. Fluorinated compounds often exhibit unique behavior in biochemical systems, such as increased lipophilicity.
  • Potential Applications: Compounds like this one could have applications in various fields including drug delivery systems, surface modification, and as biocides due to their antimicrobial properties.
  • Safety Considerations: As with many chemicals containing fluorine, it is essential to study the compound thoroughly to understand any potential toxicity or environmental impact, making it a candidate for extensive research.
  • Intermolecular Interactions: Its ability to form ionic bonds can be useful in enhancing interactions with other molecules, which is relevant in both chemical and biological contexts.

In summary, trimethyl-[3-(2,2,2-trifluoro-1,1-dihydroxy-ethyl)phenyl]ammonium is not just a compound of interest due to its functional groups, but also for its potential practical applications and the scientific questions it raises regarding its interactions and behavior in various environments. As researchers delve deeper, they may uncover even more compelling uses and characteristics.

Synonyms
m-(n,n,n-trimethylammonio)-2,2,2-trifluoro-1,1-dihydroxyethylbenzene
N,N,N-trimethyl-3-(2,2,2-trifluoro-1,1-dihydroxyethyl)anilinium
trimethyl-[3-(2,2,2-trifluoro-1,1-dihydroxyethyl)phenyl]azanium
m-trimethylammonio(2,2,2-trifluoro-1,1-dihydroxyethyl)benzene
1amn
SCHEMBL4311749
CHEBI:44394
KGVDBJQLTHWAJF-UHFFFAOYSA-N
DB03359
PD007054
NS00069510
Q27094300