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Neostigmine Iodide

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Identification
Molecular formula
C12H19N2O2I
CAS number
114-80-7
IUPAC name
trimethyl-[4-methyl-3-(methylcarbamoyloxy)phenyl]ammonium;iodide
State
State

At room temperature, Neostigmine iodide is found in the form of a solid, specifically a crystalline powder. Its stability at ambient conditions makes it suitable for use in various pharmaceutical formulations.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
244.00
Boiling point (Kelvin)
517.15
General information
Molecular weight
383.23g/mol
Molar mass
383.2320g/mol
Density
1.1000g/cm3
Appearence

Neostigmine iodide is typically found as a white or off-white crystalline powder. Its crystal structure reflects its purity and is indicative of its high degree of crystallinity, common for many ionic compounds.

Comment on solubility

Solubility of Trimethyl-[4-methyl-3-(methylcarbamoyloxy)phenyl]ammonium Iodide

The solubility of trimethyl-[4-methyl-3-(methylcarbamoyloxy)phenyl]ammonium iodide in various solvents is an intriguing topic. This compound is characterized by its quaternary ammonium structure, which influences its solubility properties significantly.

Factors Influencing Solubility

Several factors play a crucial role in determining the solubility of this compound:

  • Ionic Nature: As an iodide salt, it is likely to be more soluble in polar solvents.
  • Alkyl Chain Length: The presence of bulky methyl groups can contribute to its solubility characteristics.
  • Hydrophilicity vs. Hydrophobicity: The balance between hydrophilic (methylcarbamoyloxy functional group) and hydrophobic (alkyl groups) influences its interaction with solvents.

Expected Solubility Insights

Generally, quaternary ammonium compounds like this one display a certain level of solubility in:

  • Water: Expect moderate solubility due to the ionic iodide component.
  • Alcohols: Higher solubility in lower alcohols like methanol and ethanol is anticipated.
  • Aromatic Solvents: Limited solubility in non-polar solvents due to the presence of ionic characteristics.

In summary, while the exact solubility requires experimental determination, it is reasonable to hypothesize that trimethyl-[4-methyl-3-(methylcarbamoyloxy)phenyl]ammonium iodide will exhibit solubility trends typical of quaternary ammonium salts, favoring polar solvent interactions.

Interesting facts

Interesting Facts about Trimethyl-[4-methyl-3-(methylcarbamoyloxy)phenyl]ammonium Iodide

Trimethyl-[4-methyl-3-(methylcarbamoyloxy)phenyl]ammonium iodide is a fascinating compound with a unique structure and various applications. Here are some intriguing aspects that highlight its significance in the field of chemistry:

Chemical Structure

The compound boasts a complex molecular framework that contributes to its properties:

  • Quaternary Ammonium Salt: It is classified as a quaternary ammonium salt, which indicates that one nitrogen atom is covalently bonded to four organic groups, giving the compound its stability and unique reactivity.
  • Functional Groups: Featuring a methylcarbamoyloxy group, this compound showcases the versatility of carbamate derivatives, often used in various chemical syntheses and applications.

Applications

Trimethyl-[4-methyl-3-(methylcarbamoyloxy)phenyl]ammonium iodide has notable applications:

  • Pharmaceuticals: Compounds like this are often studied for their potential use in drug formulations, particularly in enhancing the solubility and bioavailability of active pharmaceutical ingredients.
  • Antimicrobial Agents: Some quaternary ammonium compounds are known for their antimicrobial properties, making them valuable in medical and industrial disinfectants.

Research Significance

This compound serves as an important subject of study among chemists:

  • Study of Ion Pairing: It aids in the understanding of ion pairing in solution, which is crucial in many areas of organic and medicinal chemistry.
  • Order and Disorder: Understanding how trimethyl ammonium groups interact with various anions opens avenues for the study of molecular order and disorder in material sciences.

In summary, trimethyl-[4-methyl-3-(methylcarbamoyloxy)phenyl]ammonium iodide is more than just a compound; it’s a gateway into the complexities of chemical interactions and applications. Its presence in various fields, from pharmaceuticals to materials science, emphasizes the importance of quaternary ammonium compounds in modern chemistry.
Understanding this compound can provide valuable insights into innovative applications and improvements in chemical technology.

Synonyms
TL-1071
NSC 11847
T-1708
7142-64-5
Ammonium, (3-(methylcarbamoyloxy)-p-tolyl)trimethyl-, iodide
Carbamic acid, methyl-, 5-(trimethylammonio)-o-tolyl ester, iodide
AMMONIUM, (3-HYDROXY-p-TOLYL)TRIMETHYL-, IODIDE, METHYLCARBAMATE
Methiodide of N-methylurethane of 5-dimethylamino-4-isopropyl-o-cresol
Carbamic acid, N-methyl-, 2-methyl-5-dimethylaminophenyl ester, methiodide
NSC11847
NSC-11847
WLN: 1MVOR B1 EK1&1&1 &Q &I
Carbamic acid, 2-methyl-5-(dimethylamino)phenyl ester, methiodide