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Neostigmine

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Identification
Molecular formula
C12H19N2O2
CAS number
59-99-4
IUPAC name
trimethyl-[4-(methylcarbamoyloxy)phenyl]ammonium
State
State

Under standard conditions, neostigmine is in a solid state.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
266.00
Boiling point (Kelvin)
539.15
General information
Molecular weight
303.37g/mol
Molar mass
303.3740g/mol
Density
1.3800g/cm3
Appearence

Neostigmine appears as a white crystalline powder. It is typically odorless and can absorb moisture from the air, hence it is hygroscopic.

Comment on solubility

Solubility of Trimethyl-[4-(methylcarbamoyloxy)phenyl]ammonium

The solubility of trimethyl-[4-(methylcarbamoyloxy)phenyl]ammonium is influenced by its unique molecular structure and functional groups. This compound features a quaternary ammonium group, which typically enhances solubility in polar solvents due to the presence of positive charge and intermolecular interactions.

Key Factors Affecting Solubility:

  • Polarity: The compound's polar functional groups (methylcarbamoyloxy) can facilitate solubility in polar solvents such as water and alcohols.
  • Electrostatic Interactions: The cationic nature promotes solvation, making it more soluble than its neutral counterparts.
  • Hydrogen Bonding: The presence of hydrogen bond donors and acceptors in the structure can enhance solubility.

In general, quaternary ammonium compounds tend to exhibit good solubility in aqueous environments, manifesting their utility in various industrial and pharmaceutical applications. However, the specific solubility can vary based on temperature, pH, and the presence of other solubilizing agents. It's crucial to perform solubility tests under controlled conditions to ascertain precise solubility profiles.

Interesting facts

Interesting Facts About Trimethyl-[4-(methylcarbamoyloxy)phenyl]ammonium

Trimethyl-[4-(methylcarbamoyloxy)phenyl]ammonium is a fascinating compound that plays a significant role in various scientific fields, particularly in organic chemistry and biochemistry. Here are some intriguing points about this compound:

  • Versatile Laboratory Applications: This compound is often utilized in laboratories as a reagent or intermediate in the synthesis of more complex molecules, making it valuable for chemists working on novel drug development.
  • Biological Significance: The presence of the methylcarbamoyloxy group suggests potential biological activity. Compounds containing carbamates have been studied for their various biological properties, including antimicrobial and herbicidal activities.
  • Ionization Properties: The trimethylammonium moiety in this compound contributes to its behavior as a quaternary ammonium salt, which can significantly influence solubility and ionization in polar media. This can enhance its reactivity in different chemical reactions.
  • Structure-Activity Relationship: Researchers often examine how structural variations in compounds like trimethyl-[4-(methylcarbamoyloxy)phenyl]ammonium can affect their biological activity. This makes it a pivotal point of interest in medicinal chemistry.
  • Potential for Drug Development: The exploration of compounds with similar structures has led to advancements in pharmaceuticals. Understanding this compound’s reactivity and interactions could pave the way for innovative therapeutic agents.

In summary, trimethyl-[4-(methylcarbamoyloxy)phenyl]ammonium is not just another chemical compound; it holds potential in organic synthesis and medicinal chemistry, showcasing the intricate relationship between structure, reactivity, and biological activity.

Synonyms
24474-85-9
78K68JSG8C
4-[[(Methylamino)carbonyl]oxy]-N,N,N-trimethylbenzenaminium
Ammonium, (p-hydroxyphenyl)trimethyl-, methylcarbamate (ester)
N,N,N-Trimethyl-4-[[(methylamino)carbonyl]oxy]benzenaminium
Benzenaminium, N,N,N-trimethyl-4-[[(methylamino)carbonyl]oxy]-
Carbamic acid, methyl-, ester with (p-hydroxyphenyl)trimethylammonium