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Hexamethonium bromide

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Identification
Molecular formula
C12H30N2Br2
CAS number
80-40-0
IUPAC name
trimethyl-[6-(trimethylammonio)hexyl]ammonium;dibromide
State
State

Hexamethonium bromide is in a solid state at room temperature. It commonly appears as a crystalline substance under standard conditions.

Melting point (Celsius)
141.00
Melting point (Kelvin)
414.00
Boiling point (Celsius)
250.00
Boiling point (Kelvin)
523.00
General information
Molecular weight
458.34g/mol
Molar mass
458.3360g/mol
Density
1.1000g/cm3
Appearence

Hexamethonium bromide typically appears as a white to off-white crystalline powder. The compound is hygroscopic and tends to absorb moisture from the environment.

Comment on solubility

Solubility of Trimethyl-[6-(trimethylammonio)hexyl]ammonium Dibromide

Trimethyl-[6-(trimethylammonio)hexyl]ammonium dibromide (C12H30N2Br2) exhibits interesting solubility characteristics due to its quaternary ammonium structure. Here are some notable points about its solubility:

  • Polarity: The presence of charged ammonium groups in the molecule contributes to its polar nature. This enhances its solubility in polar solvents such as water.
  • Solvent Compatibility: Generally, quaternary ammonium salts exhibit high solubility in water and other polar solvents but may be less soluble in non-polar solvents.
  • Concentration Effects: Increasing the concentration of trimethyl-[6-(trimethylammonio)hexyl]ammonium dibromide can lead to saturation in aqueous solutions, potentially resulting in precipitation if the solubility limit is exceeded.
  • Temperature Influence: As with many ionic compounds, solubility can increase with higher temperatures, enhancing its dissociation in solvent.

In summary, the solubility of trimethyl-[6-(trimethylammonio)hexyl]ammonium dibromide is significantly affected by both its molecular structure and the solvent conditions. Its tendency to dissolve in polar solvents is a defining characteristic of its chemical behavior.

Interesting facts

Interesting Facts About Trimethyl-[6-(trimethylammonio)hexyl]ammonium Dibromide

Trimethyl-[6-(trimethylammonio)hexyl]ammonium dibromide is a fascinating quaternary ammonium compound that showcases a unique blend of properties associated with both organic and inorganic chemistry. Here are some notable aspects:

  • Structure and Composition: The compound features a central nitrogen atom quaternized by three methyl groups and linked to a hexyl chain with an additional trimethylammonio group. This makes it a cationic surfactant, which allows it to interact effectively with various substrates.
  • Applications: It is commonly used in laboratories and industries for its surfactant properties. Common applications include:
    • As a phase-transfer catalyst in chemical reactions.
    • In the development of antimicrobial agents due to its ability to disrupt cell membranes.
    • As a coating agent for enhancing the protection of surfaces against corrosion.
  • Biological Significance: The compound's cationic nature allows it to interact with biological membranes, which can influence cell permeability. As a result, it has been studied for potential applications in drug delivery systems to enhance the bioavailability of therapeutic agents.
  • Toxicity Considerations: While it exhibits many positive properties, it’s important to note that certain quaternary ammonium compounds can be toxic at higher concentrations. Therefore, safe handling and environmental studies are crucial for its use.
  • Research and Development: Ongoing research is exploring the role of similar compounds in innovative areas such as nanotechnology and material science, where their amphiphilic characteristics can be exploited for creating novel materials.

In summary, Trimethyl-[6-(trimethylammonio)hexyl]ammonium dibromide stands out not only for its intriguing chemical structure but also for its diverse applications, making it an essential subject of study in both academic and industrial settings. Its dual functionality as a surfactant and potential medicinal agent highlights the endless possibilities present in the world of chemical compounds.

Synonyms
HEXAMETHONIUM BROMIDE
55-97-0
Bistrium bromide
Hexamethionium bromide
Esametina
Gangliostat
Hexameton
Vegolysen
Vegolysin
Hexamethonium dibromide
Hexonium dibromide
Simpatoblock
Bromuro de hexametonio
Bromure d'hexamethonium
Hexamethonium (Bromide)
Esametonio bromuro
Esametonio bromuro [DCIT]
Hexamethonii bromidum
Hexamethonium (dibromure d')
HEXAMETHONE BROMIDE
Hexamethylenebis(trimethylammonium bromide)
1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide
Hexamethonii bromidum [INN-Latin]
EINECS 200-249-7
Bromure d'hexamethonium [INN-French]
Bromuro de hexametonio [INN-Spanish]
Hexamethonium bromide [INN:BAN:JAN]
NSC 163965
Hexamethylenebis(trimethylammonium) bromide
Ammonium, hexamethylenebis(trimethyl-, dibromide
N1,N1,N1,N6,N6,N6-hexamethylhexane-1,6-diaminium bromide
8J77X3S603
NSC-163965
Hexamethonium bromide (TN)
Hexane-1,6-bis(trimethylammonium bromide)
DTXSID50883229
HEXAMETHONIUM BROMIDE [MI]
alpha, omega-Bis(trimethyl ammonium)hexane dibromide
HEXAMETHONIUM BROMIDE [INN]
HEXAMETHONIUM BROMIDE [JAN]
1,6-Hexanediaminium, N1,N1,N1,N6,N6,N6-hexamethyl-, bromide (1:2)
HEXAMETHONIUM BROMIDE [MART.]
HEXAMETHONIUM BROMIDE [WHO-DD]
Hexamethonii bromidum (INN-Latin)
Bromure d'hexamethonium (INN-French)
Bromuro de hexametonio (INN-Spanish)
HEXAMETHONIUM BROMIDE (MART.)
CHEMBL332524
NSC163965
SR-01000075320
UNII-8J77X3S603
Hexamethoniumbromide
hexamAthonium (cation)
SCHEMBL143264
SPECTRUM1503297
trimethyl-[6-(trimethylazaniumyl)hexyl]azanium;dibromide
HMS502B05
Hexamethonium bromide (JAN/INN)
DTXCID801022778
HMS1922A08
HMS3261N06
BCP24467
HY-B0569
Tox21_500622
CCG-39330
MFCD00011787
s4069
AKOS015832953
benzohexonium (for the benzosulfonate)
LP00622
NCGC00093993-01
NCGC00093993-02
NCGC00093993-03
NCGC00261307-01
AS-57514
hexamethylene-bis(trimethylammonium)bromide
DB-052826
EU-0100622
H0481
NS00078992
D02204
D90883
H 0879
SR-01000075320-2
SR-01000075320-9
Q27270624
trimethyl[6-(trimethylazaniumyl)hexyl]azanium dibromide
1,6-Hexanediaminium, N,N,N,N',N',N'-hexamethyl-, dibromide (9CI)
200-249-7