Ketoconazole

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Identification

Molecular formula
C26H28Cl2N4O4
CAS Number
65277-42-1
IUPAC Name
1-[4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
Molecular Weight
531.43g/mol
Melting Point
(Celsius)
Boiling Point
(Celsius)
Density
1.3200g/cm3
Synonyms
ketoconazole
Interesting facts

Interesting Facts about 1-[4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone

This compound is a noteworthy member of the class of piperazine derivatives, which have gained significant attention in medicinal chemistry. Here are some intriguing points regarding this unique compound:

  • Pharmacological Potential: Compounds like this one often exhibit biological activities that may be beneficial in treating various conditions, including but not limited to anxiety and depression. The structural diversity provided by the imidazole and dioxolane moieties might enhance its interaction with biological targets.
  • Complex Structure: Featuring an intricate arrangement of functional groups, this compound serves as a fascinating example of how slight modifications to a molecular structure can drastically change its properties and biological activities. The presence of the 2,4-dichlorophenyl ring highlights the importance of chlorinated compounds in pharmaceuticals, as halogenation can tune the lipophilicity and bioactivity.
  • Research Significance: This compound could be pivotal in ongoing research for developing new therapies. The blend of piperazine and imidazole rings could lead to innovative treatments, enhancing our understanding of drug design and efficacy.
  • Synthetic Routes: The synthesis of such compounds involves intricate organic reactions, showcasing the art of synthetic chemistry. Understanding the methods used to construct such diverse elements contributes to the skill set required in modern chemistry laboratories.
  • Analytical Techniques: The complexity of this compound necessitates the use of advanced analytical techniques for characterization, such as NMR, mass spectrometry, and X-ray crystallography, reinforcing the essential role of these methods in drug development.

In conclusion, 1-[4-[4-[[2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone is not just a compound of interest due to its potential therapeutic applications; it is also an excellent demonstration of the complexities and intricacies involved in modern medicinal chemistry.

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