Decitabine

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Identification

Molecular formula
C8H12N4O4
CAS Number
2353-33-5
IUPAC Name
2-(4-amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
Molecular Weight
228.21g/mol
Melting Point
(Celsius)
Boiling Point
(Celsius)
Density
1.8754g/cm3
Synonyms
7-Iodo-7-deaza-D-guanosine
Interesting facts

Interesting Facts about 2-(4-amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol

This compound is a fascinating molecule, noteworthy for its complex structure and potential applications in medicinal chemistry. As a derivative of pyrrolo-pyrimidine, it is particularly interesting due to the presence of the iodo substituent which can significantly influence the compound's reactivity and biological activities. Here are some engaging aspects of this compound:

  • Biological Significance: Compounds like this one are often studied for their roles as potential therapeutic agents, especially in the context of cancer treatments and antiviral applications.
  • Structural Diversity: The inclusion of both a pyrrolo and a pyrimidine moiety in its structure enables a range of interactions with biological targets, enhancing its usefulness in drug design.
  • Functional Groups: The hydroxymethyl group presents opportunities for further modifications, which could be exploited for increasing bioactivity or solubility.
  • Iodine's Role: The presence of iodine in the compound often affects pharmacokinetics, including absorption and distribution within biological systems, making iodine-containing compounds a topic of interest in radiological studies.

Moreover, the examination of compounds with such intricate chemical frameworks has been enriched by advancements in spectroscopy and computational chemistry, allowing scientists to explore their properties more thoroughly. As noted by researchers, “Understanding the nuances of structure-activity relationships in such compounds is key to unlocking their therapeutic potential.”

In summary, 2-(4-amino-5-iodo-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol represents a compelling example of how complex organic molecules can pave the way for innovations in pharmaceuticals.

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