Entrectinib

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Identification

Molecular formula
C31H34ClN5O3
CAS Number
1108743-60-7
IUPAC Name
3-amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide
Molecular Weight
560.09g/mol
Melting Point
(Celsius)
Boiling Point
(Celsius)
Density
1.4236g/cm3
Synonyms
EIPA
Interesting facts

Interesting Facts about 3-amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide

The compound 3-amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide presents a fascinating structure that has garnered interest in the field of medicinal chemistry. Its complex molecular architecture includes several key functional groups that significantly contribute to its chemical behavior:

  • Amino Groups: The presence of multiple amino groups opens avenues for hydrogen bonding, which can impact solubility and biological interactions.
  • Chloro Substituent: Chlorine atoms in organic compounds often enhance lipophilicity and can influence the reactivity of the compound.
  • Pyrazine Ring: This bicyclic structure is commonly found in various pharmaceuticals and can play a crucial role in biological activity.

Moreover, the specific arrangement of ethyl and isopropyl groups surrounding the amino moiety can lead to subtle changes in pharmacodynamics and pharmacokinetics. As a result, the compound could serve as a potential candidate for developing therapeutic agents targeting specific biochemical pathways.

Applications and Research Directions

Here are some intriguing applications and research directions related to this compound:

  • Anticancer Research: Compounds with similar structures have been investigated for their potential to inhibit tumor growth.
  • Antimicrobial Activity: The various substituents might enhance the compound's efficacy against bacterial or fungal strains.
  • Structure-Activity Relationship (SAR) Studies: Understanding how modifications to the molecular structure affect the activity will be crucial for drug design and development.

In summary, the intricate structure and promising biological potential of 3-amino-6-chloro-N-(diaminomethylene)-5-[ethyl(isopropyl)amino]pyrazine-2-carboxamide make it a subject of considerable interest in the chemical and pharmaceutical fields. Further investigation could reveal new therapeutic options and deepen our understanding of related compounds.

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