Tenofovir alafenamide

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Identification

Molecular formula
C21H29O5P
CAS Number
379270-37-8
IUPAC Name
[[[[5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]-difluoro-methyl]phosphonic acid
Molecular Weight
476.48g/mol
Melting Point
(Celsius)
Boiling Point
(Celsius)
Density
1.5000g/cm3
Appearance
can vary slightly depending on the form in which it is found. It is usually observed as a crystalline powder that is highly soluble in water.
Interesting facts

Interesting Facts About 5-(6-Aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl Methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl-difluoro-methyl Phosphonic Acid

This intricate compound, intriguingly named 5-(6-aminopurin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl-difluoro-methyl phosphonic acid, embodies the fascinating world of medicinal chemistry and biochemical research. Here are some notable facts about it:

  • Role in Biochemistry: This compound is of significant interest in the study of nucleotides and nucleosides, especially related to nucleotide metabolism and their role in genetic expression.
  • Research Implications: The presence of aminopurine highlights its potential influence on various biological pathways, and it could be investigated for use in therapies against certain diseases, particularly those associated with cellular dysfunction.
  • Potential Analogues: Given its structure, it may serve as a scaffold for the design of new pharmaceuticals, allowing modifications to improve efficacy and selectivity in targeting specific biological molecules.
  • Phosphonic Acids: Compounds in this category often function as enzyme inhibitors, providing a possible mechanism to regulate metabolic pathways, thus presenting both challenges and opportunities in drug design.
  • Synthetic Challenges: The complexity of its synthesis may require advanced organic chemistry techniques, making it a favorite topic for discussion in synthetic methodology courses.

As a combination of various functional groups, this compound exemplifies how slight changes in molecular structure can lead to significant variations in biological activity, raising endless questions and possibilities for researchers in the field.
This compound truly represents the intricate dance between chemistry and biology!

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