Estradiol

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Identification

Molecular formula
C18H24O2
CAS Number
50-28-2
IUPAC Name
(8R,9S,10R,13S,14S,17S)-17-[(1R)-1-hydroxyethyl]-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
Molecular Weight
272.39g/mol
Melting Point
(Celsius)
Boiling Point
(Celsius)
Density
1.1659g/cm3
Synonyms
OXOGESTONE
Interesting facts

Interesting Facts about (8R,9S,10R,13S,14S,17S)-17-[(1R)-1-hydroxyethyl]-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one

This complex organic compound belongs to the class of steroids and is notable for its unique stereochemistry, which heavily influences its biological activity. Here are some fascinating points about this compound:

  • Stereochemistry: The specific stereochemical configuration (including the (8R,9S,10R) and other notations) suggests that this compound possesses multiple chiral centers. Each of these centers can significantly affect the compound's interaction with biological systems.
  • Biological Relevance: Compounds like this are often investigated for their potential pharmacological applications, particularly as hormone mimetics or in the study of endocrine functions. Understanding how the structure relates to function is key in medicinal chemistry.
  • Synthetic Pathways: The synthesis of such compounds can be intricate. Scientists may utilize various organic reactions, including cyclization and functional group modifications, to achieve the desired structure. Exploring these synthetic methods opens up discussions about green chemistry and sustainable practices.
  • Analytical Techniques: To characterize and confirm the structure of this compound, chemists might employ techniques such as NMR spectroscopy, mass spectrometry, and X-ray crystallography. Each technique provides unique insights into the molecular structure and properties.
  • Potential Uses: Due to its structure, which may resemble certain steroid hormones, this compound could potentially be explored for use in therapies related to hormonal imbalances or certain types of cancer.

In summary, (8R,9S,10R,13S,14S,17S)-17-[(1R)-1-hydroxyethyl]-13-methyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one is not only a fascinating molecule because of its intricate structure, but it also stands at the intersection of organic chemistry and biochemistry, highlighting the significance of chirality and biological interactions in the development of new therapeutic agents.

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